Validation of DMLs identified in the current (Gong) study using TCGA cohort.

• Main Authors: Zhihong Gong (448693), Jianhong Chen (1632946), Jie Wang (16762), Song Liu (9858), Christine B. Ambrosone (8954762), Michael J. Higgins (153782)
• Format: Other Non-Article Part of Journal/Newspaper
• Language: unknown
• Published: 2021
• Subjects: Biophysics; Cell Biology; Genetics; Molecular Biology; Cancer; Biological Sciences not elsewhere classified; Chemical Sciences not elsewhere classified; DNA methylation patterns; EA women; DNA methylation-dysregulated miRNAs; DML; EMT; FDR; ER; miRNA encoding genes; TCGA; American women; cell cycle G 1-S growth factor regu.; breast cancer subtypes; breast cancer; differentially methylated loci; European ancestry Aggressive; miRNA expression; genome-wide methylation screen; DNA methylation changes; AA; ESR; genome-wide DNA methylation-based m.
• Online Access: https://doi.org/10.1371/journal.pone.0249229.s006

(A and B) Scatter plot of delta beta value of available DMLs from Gong (x-axis) versus TCGA (y-axis) in AAs (A) and in EAs (B). DMLs identified in both data with consistent direction of methylation changes and FDR-adjusted P <0.05 are plotted as black dots. DMLs identified in the Gong study with consistent direction of methylation changes but did not reach statistical significance in TCGA data (dots in red). (PDF)