Validation of DMLs identified in the current (Gong) study using TCGA cohort.

(A and B) Scatter plot of delta beta value of available DMLs from Gong (x-axis) versus TCGA (y-axis) in AAs (A) and in EAs (B). DMLs identified in both data with consistent direction of methylation changes and FDR-adjusted P <0.05 are plotted as black dots. DMLs identified in the Gong study with...

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Bibliographic Details
Main Authors: Zhihong Gong (448693), Jianhong Chen (1632946), Jie Wang (16762), Song Liu (9858), Christine B. Ambrosone (8954762), Michael J. Higgins (153782)
Format: Other Non-Article Part of Journal/Newspaper
Language:unknown
Published: 2021
Subjects:
Biophysics
Cell Biology
Genetics
Molecular Biology
Cancer
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
DNA methylation patterns
EA women
DNA methylation-dysregulated miRNAs
DML
EMT
FDR
ER
miRNA encoding genes
TCGA
American women
cell cycle G 1-S growth factor regu.
breast cancer subtypes
breast cancer
differentially methylated loci
European ancestry Aggressive
miRNA expression
genome-wide methylation screen
DNA methylation changes
AA
ESR
genome-wide DNA methylation-based m.
Online Access:https://doi.org/10.1371/journal.pone.0249229.s006
Description
Summary:(A and B) Scatter plot of delta beta value of available DMLs from Gong (x-axis) versus TCGA (y-axis) in AAs (A) and in EAs (B). DMLs identified in both data with consistent direction of methylation changes and FDR-adjusted P <0.05 are plotted as black dots. DMLs identified in the Gong study with consistent direction of methylation changes but did not reach statistical significance in TCGA data (dots in red). (PDF)

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