Diet and Life Stage-Associated Lipidome Remodeling in Atlantic Salmon

• Main Authors: Yang Jin (78609), Thomas Nelson Harvey (9612229), Zdenka Bartosova (10356108), Sahar Hassani (139319), Per Bruheim (2300677), Simen Rød Sandve (9612235), Jon Olav Vik (9666588)
• Format: Other Non-Article Part of Journal/Newspaper
• Language: unknown
• Published: 2021
• Subjects: Biochemistry; Cell Biology; Ecology; Sociology; Inorganic Chemistry; Environmental Sciences not elsewhere classified; Biological Sciences not elsewhere classified; Chemical Sciences not elsewhere classified; FW fish; LC-HUFA; lipoprotein formation genes; Atlantic Salmon Salmon; diet; DHA; life stage-specific features; PE; PC; lipid synthesis genes; gut; SW fish; Life Stage-Associated Lipidome Remo.; Atlantic salmon
• Online Access: https://doi.org/10.1021/acs.jafc.0c07281.s001

Salmon is an important source of long-chain highly unsaturated fatty acids (LC-HUFAs) such as 22:6 n -3 [docosahexaenoic acid (DHA)]. In the present study, we conducted two identical experiments on salmon in freshwater (FW) and seawater (SW) stages, with a diet switch from fish oil (high in LC-HUFA) to vegetable oil (low in LC-HUFA) and vice versa. Our aim was to investigate the diet and life stage-specific features of lipid uptake (gut), processing (liver), and deposition (muscle). The lipid composition changed much faster in the gut of SW fish relative to FW fish, suggesting that the former had a higher rate of lipid absorption and transport. SW fish also had higher expression of phospholipid synthesis and lipoprotein formation genes in the gut, whereas FW fish had higher expression of lipid synthesis genes in the liver. All phospholipids except PC-44:12 and PE-44:12 were less abundant in SW, suggesting that SW fish have a higher requirement for DHA.