| Summary: | (A) Phylogenetic occurrence of IRF- and IFN-dependent innate immune response. The selection of individual species is based on literature indicating certain effects and is not intended to be comprehensive. In cnidarians and bilaterians, which diverged from the common eumetazoan ancestor ~600–630 million years ago, IRFs are proposed to be separated into IRF1 and IRF4 subfamilies. (B) Evolutionary comparison of vertebrate IRF1 and invertebrate IRF1-like genes within the DBD. *, C . gigas ‘IRF1’ gene that has been reported. Three other predicted transcript variants of Pacific oyster IRF1 exist (LOC105343806; NCBI Accession numbers: XM_011451290.2 for X1, XM_011451291.2 for X2 and XM_011451292.2 for X3). The predicted amino acid sequence shares 53% identity with H . sapiens IRF1 at the DBD, and contains all five tryptophans as well as the conserved GAAA-contacting residues. LOC105343805 thus might not represent bona fide C . gigas IRF1. **, B . belcheri ‘IRF1’ does not present a rigid one-to-one ortholog relationship with vertebrate IRF1. Rather, it is linked to the vertebrate IRF1 subfamily based on phylogenetic analysis.
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