| Summary: | Transdermal drug delivery is a technique that can make drug delivery more convenient for patients. It enables drugs to be delivered through patches, similar to bandages, replacing some other common methods, such as oral delivery and hypodermic injection. Systems of this kind are complex and a number of parameters can affect the delivery characteristics. Hence, design of transdermal drug delivery systems traditionally requires extensive and time consuming experimentation. In this work a multilayer numerical model is developed for controlled transdermal drug delivery from a patch. The model is based on Fickian diffusion and takes into account key parameters that define the skin permeability, such as partition between layers, due to difference in solubility, and mass transfer due to surface barrier. Numerical models, such as the one described in this thesis, can reduce the development time traditionally required to produce transdermal drug delivery systems by rapidly simulating and comparing different design choices. The project is a collaboration between the Faculty of Industrial Engineering, Mechanical Engineering and Computer Science and the Faculty of Pharmaceutical Sciences, at the University of Iceland and previous results are extended in this work. The parameters of the model are validated by using experimental data provided by the Faculty of Pharmaceutical Sciences. Results from the numerical model compared well with experimental data. However, further work is required due to the complexity of the experiments and number of parameters affecting the process. The conclusion of this thesis is that the model can be a valuable aid in the design of transdermal drug delivery systems. Stýrð losun lyfja í gegnum húð er aðferð sem getur gert inntöku lyfja þægilegri fyrir sjúklinga. Aðferðin gerir lyfjum kleift að vera losuð í gegnum plástra, og getur komið í stað annarra algengra aðferða, sem dæmi má nefna inntökulyf. Kerfi sem slík eru flókin og margar breytistærðir geta haft áhrif á losunarferlið. Þar af leiðandi ...
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