Different tumor types from BRCA2 carriers show wild-type chromosome deletions on 13q12-q13

• Main Authors: Sigurður Ingvarsson 1956-, Júlíus Guðmundsson 1968-, Guðrún Jóhannesdóttir 1957-, Jón Þór Bergþórsson 1966-, Aðalgeir Arason 1957-, Valgarður Egilsson 1940-, Rósa Björk Barkardóttir 1958-
• Other Authors: Háskóli Íslands
• Format: Article in Journal/Newspaper
• Language: English
• Published: 1995
• Subjects: Iceland
• Online Access: http://hdl.handle.net/1946/20737

In this study we examined loss of heterozygosity (LOH) on chromosome 13q12-13 in 50 tumors from BRCA2 carriers in five families showing strong evidence of linkage to BRCA2. In addition to high frequency of LOH in female breast cancer, LOH was observed in tumors of the prostate, ovary, cervix, colon, male breast, and ureter. All detected losses involved the wild-type chromosome. These results suggest that BRCA2 is a tumor suppressor gene and may be involved in the tumorigenesis of several cancer types in addition to breast cancer. This work was supported by the Nordic Cancer Union, the Science Fund of Iceland,the University of Iceland Graduate Research Fund, the Science Fund of the University Hospital of Iceland, and Ihc Memorial Fund of Bergthora Magnusdottir and Jakob B. Bjarnason.