Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses

• Published in: Scientific Reports
• Main Authors: Ghawar, Wissem, Pascalis, Hervé, Bettaieb, Jihéne, Mélade, Julien, Gharbi, Adel, Snoussi, Mohamed Ali, Laouini, Dhafer, Goodman, Steven M., Salah, Afif Ben, Dellagi, Koussay
• Other Authors: Université de Tunis El Manar (UTM), Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP), Centre de Recherche et de Veille sur les Maladies Émergentes dans l'Océan Indien (CRVOI), Université de La Réunion (UR), Processus Infectieux en Milieu Insulaire Tropical (PIMIT), Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IRD-Centre National de la Recherche Scientifique (CNRS), Association Vahatra Antananarivo, Madagascar, Field Museum of Natural History Chicago, USA, Cyclotron Réunion Océan Indien (CYROI), Université de La Réunion (UR)-Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Laboratoire de Transmission, Contrôle et Immunobiologie des Infections - Laboratory of Transmission, Control and Immunobiology of Infection (LR11IPT02), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)
• Format: Article in Journal/Newspaper
• Language: English
• Published: HAL CCSD 2017
• Subjects: [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology; [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases; [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases; Rattus rattus
• Online Access: https://hal.science/hal-01534743; https://hal.science/hal-01534743/document; https://hal.science/hal-01534743/file/Insight%20into%20the%20global.pdf; https://doi.org/10.1038/s41598-017-02206-0

cited By 0 International audience One portion of the family Paramyxoviridae is a group of Unclassified Morbilli-Related Viruses (UMRV) recently recognized in wild small mammals. At a global level, the evolutionary history of these viruses is not properly understood and the relationships between UMRV and their hosts still remain largely unstudied. The present study revealed, for the first time, that Rodentia associated UMRV emerged from a common ancestor in southern Africa more than 4000 years ago. Sequenced UMRV originating from different regions in the world, clustered into four well-supported viral lineages, which suggest that strain diversification occurred during host dispersal and associated exchanges, with purifying selection pressure as the principal evolutionary force. In addition, multi-introductions on different continents and islands of Rodentia associated UMRV and spillover between rodent species, most probably Rattus rattus, were detected and indicate that these animals are implicated in the vectoring and in the worldwide emergence of this virus group. The natural history and the evolution dynamics of these zoonotic viruses, originating from and hosted by wild animals, are most likely shaped by commensalism related to human activities.