Determination of Ligand Pathways in Globins: Apolar Tunnels Versus Polar Gates

Background: O2 pathways in animal hemoglobins and myoglobins are controversial. Results: Ligands enter and exit sperm whale Mb and Cerebratulus lacteus Hb by completely different pathways. Conclusion: Rational mutagenesis mapping can identify ligand migration pathways and provides experimental bench...

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Published in:Journal of Biological Chemistry
Main Authors: Salter, Mallory D., Blouin, George C., Soman, Jayashree, Singleton, Eileen W., Dewilde, Sylvia, Moens, Luc, Pesce, Alessandra, Nardini, Marco, Bolognesi, Martino, Olson, John S.
Format: Article in Journal/Newspaper
Language:English
Published: The American Society for Biochemistry and Molecular Biology, Inc. 2012
Subjects:
Sperm whale
Online Access:https://hdl.handle.net/1911/70807
https://doi.org/10.1074/jbc.M112.392258
id ftriceuniv:oai:scholarship.rice.edu:1911/70807
record_format openpolar
spelling ftriceuniv:oai:scholarship.rice.edu:1911/70807 2023-06-11T04:17:06+02:00 Determination of Ligand Pathways in Globins: Apolar Tunnels Versus Polar Gates Salter, Mallory D. Blouin, George C. Soman, Jayashree Singleton, Eileen W. Dewilde, Sylvia Moens, Luc Pesce, Alessandra Nardini, Marco Bolognesi, Martino Olson, John S. 2012 application/pdf https://hdl.handle.net/1911/70807 https://doi.org/10.1074/jbc.M112.392258 eng eng The American Society for Biochemistry and Molecular Biology, Inc. Salter, Mallory D., Blouin, George C., Soman, Jayashree, et al. "Determination of Ligand Pathways in Globins: Apolar Tunnels Versus Polar Gates." The Journal of Biological Chemistry, 287, no. 40 (2012) The American Society for Biochemistry and Molecular Biology, Inc.: 33163-33178. http://dx.doi.org/10.1074/jbc.M112.392258. https://hdl.handle.net/1911/70807 http://dx.doi.org/10.1074/jbc.M112.392258 Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. Journal article Text publisher version 2012 ftriceuniv https://doi.org/10.1074/jbc.M112.392258 2023-05-06T22:30:38Z Background: O2 pathways in animal hemoglobins and myoglobins are controversial. Results: Ligands enter and exit sperm whale Mb and Cerebratulus lacteus Hb by completely different pathways. Conclusion: Rational mutagenesis mapping can identify ligand migration pathways and provides experimental benchmarks for testing molecular dynamics simulations. Significance: Globins can use either a polar gate or an apolar tunnel for ligand entry. Article in Journal/Newspaper Sperm whale Rice University: Digital Scholarship Archive Journal of Biological Chemistry 287 40 33163 33178
institution Open Polar
collection Rice University: Digital Scholarship Archive
op_collection_id ftriceuniv
language English
description Background: O2 pathways in animal hemoglobins and myoglobins are controversial. Results: Ligands enter and exit sperm whale Mb and Cerebratulus lacteus Hb by completely different pathways. Conclusion: Rational mutagenesis mapping can identify ligand migration pathways and provides experimental benchmarks for testing molecular dynamics simulations. Significance: Globins can use either a polar gate or an apolar tunnel for ligand entry.
format Article in Journal/Newspaper
author Salter, Mallory D.
Blouin, George C.
Soman, Jayashree
Singleton, Eileen W.
Dewilde, Sylvia
Moens, Luc
Pesce, Alessandra
Nardini, Marco
Bolognesi, Martino
Olson, John S.
spellingShingle Salter, Mallory D.
Blouin, George C.
Soman, Jayashree
Singleton, Eileen W.
Dewilde, Sylvia
Moens, Luc
Pesce, Alessandra
Nardini, Marco
Bolognesi, Martino
Olson, John S.
Determination of Ligand Pathways in Globins: Apolar Tunnels Versus Polar Gates
author_facet Salter, Mallory D.
Blouin, George C.
Soman, Jayashree
Singleton, Eileen W.
Dewilde, Sylvia
Moens, Luc
Pesce, Alessandra
Nardini, Marco
Bolognesi, Martino
Olson, John S.
author_sort Salter, Mallory D.
title Determination of Ligand Pathways in Globins: Apolar Tunnels Versus Polar Gates
title_short Determination of Ligand Pathways in Globins: Apolar Tunnels Versus Polar Gates
title_full Determination of Ligand Pathways in Globins: Apolar Tunnels Versus Polar Gates
title_fullStr Determination of Ligand Pathways in Globins: Apolar Tunnels Versus Polar Gates
title_full_unstemmed Determination of Ligand Pathways in Globins: Apolar Tunnels Versus Polar Gates
title_sort determination of ligand pathways in globins: apolar tunnels versus polar gates
publisher The American Society for Biochemistry and Molecular Biology, Inc.
publishDate 2012
url https://hdl.handle.net/1911/70807
https://doi.org/10.1074/jbc.M112.392258
genre Sperm whale
genre_facet Sperm whale
op_relation Salter, Mallory D., Blouin, George C., Soman, Jayashree, et al. "Determination of Ligand Pathways in Globins: Apolar Tunnels Versus Polar Gates." The Journal of Biological Chemistry, 287, no. 40 (2012) The American Society for Biochemistry and Molecular Biology, Inc.: 33163-33178. http://dx.doi.org/10.1074/jbc.M112.392258.
https://hdl.handle.net/1911/70807
http://dx.doi.org/10.1074/jbc.M112.392258
op_rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
op_doi https://doi.org/10.1074/jbc.M112.392258
container_title Journal of Biological Chemistry
container_volume 287
container_issue 40
container_start_page 33163
op_container_end_page 33178
_version_ 1768375937574895616

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