Determination of Ligand Pathways in Globins: Apolar Tunnels Versus Polar Gates
Background: O2 pathways in animal hemoglobins and myoglobins are controversial. Results: Ligands enter and exit sperm whale Mb and Cerebratulus lacteus Hb by completely different pathways. Conclusion: Rational mutagenesis mapping can identify ligand migration pathways and provides experimental bench...
Published in: | Journal of Biological Chemistry |
---|---|
Main Authors: | , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
The American Society for Biochemistry and Molecular Biology, Inc.
2012
|
Subjects: | |
Online Access: | https://hdl.handle.net/1911/70807 https://doi.org/10.1074/jbc.M112.392258 |
Summary: | Background: O2 pathways in animal hemoglobins and myoglobins are controversial. Results: Ligands enter and exit sperm whale Mb and Cerebratulus lacteus Hb by completely different pathways. Conclusion: Rational mutagenesis mapping can identify ligand migration pathways and provides experimental benchmarks for testing molecular dynamics simulations. Significance: Globins can use either a polar gate or an apolar tunnel for ligand entry. |
---|