Enzyme-catalyzed cascade synthesis of hydroxyiminoacetamides
In order to synthesize N-(3-azido-1- phenylpropyl)-2-hydroxyiminoacetamide, a key compound for the preparation of acetylcholinesterase (AChE) reactivators of the N- substituted 2-hydroxyiminoacetamide type, it was necessary to develop a method for forming an amide bond between an ethyl glyoxylate ox...
Published in: | Tetrahedron Letters |
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Main Authors: | , , , |
Format: | Article in Journal/Newspaper |
Language: | Croatian |
Published: |
Elsevier
2014
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Subjects: | |
Online Access: | http://fulir.irb.hr/3660/ http://fulir.irb.hr/3660/1/Tetr%20Lett%20postprint.pdf http://www.sciencedirect.com/science/article/pii/S0040403914010065 https://doi.org/10.1016/j.tetlet.2014.06.027 |
Summary: | In order to synthesize N-(3-azido-1- phenylpropyl)-2-hydroxyiminoacetamide, a key compound for the preparation of acetylcholinesterase (AChE) reactivators of the N- substituted 2-hydroxyiminoacetamide type, it was necessary to develop a method for forming an amide bond between an ethyl glyoxylate oxime and an amine. Using Candida antarctica lipase B (CAL-B) in a cascade enzyme-BOP catalyzed reaction, the efficient synthesis of the target hydroxyiminoacetamide was achieved. |
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