Characteristics of a cetacean morbillivirus isolated from a porpoise (Phocoena phocoena)

A virus isolated from a porpoise during the 1988 seal epizootic was shown to be a morbillivirus. In order to determine the relationship of the virus to phocine distemper virus (PDV) a battery of monoclonal antibodies raised against canine distemper virus (CDV), PDV or the porpoise isolate were asses...

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Bibliographic Details
Main Authors: Welsh, M J, Lyons, C, Trudgett, A, Rima, B K, McCullough, S J, Orvell, C
Format: Article in Journal/Newspaper
Language:English
Published: 1992
Subjects:
Animals
Antibodies
Monoclonal
Antigens
Viral
Distemper Virus
Canine
Dolphins
Enzyme-Linked Immunosorbent Assay
Fluorescent Antibody Technique
Hybridomas
Mice
Inbred BALB C
Paramyxoviridae
Vero Cells
Viral Proteins
Phocoena phocoena
Online Access:https://pure.qub.ac.uk/en/publications/d4af5b13-4627-4aa2-ab51-f1cf3d25ab09
Description
Summary:A virus isolated from a porpoise during the 1988 seal epizootic was shown to be a morbillivirus. In order to determine the relationship of the virus to phocine distemper virus (PDV) a battery of monoclonal antibodies raised against canine distemper virus (CDV), PDV or the porpoise isolate were assessed for their ability to bind to CDV, PDV or porpoise virus epitopes in indirect immunofluorescence assays and ELISAs. The porpoise isolate contained several unique epitopes and several epitopes present on CDV and PDV were absent on the porpoise isolate. The data presented in this study indicate that the porpoise virus is an antigenically distinct morbillivirus and as such has been tentatively named as delphinoid distemper virus (DDV).

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