Pacific oyster-derived polysaccharides attenuate allergen-induced intestinal inflammation in a murine model of food allergy
Oyster-derived polysaccharides (OPS) have been shown to modulate the T helper (Th)1/Th2 immunobalance toward the Th1-dominant direction in antigen-primed splenocytes. In the present study, we hypothesized that OPS might attenuate intestinal inflammation associated with food allergy, a Th2-dominant i...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345417/ http://www.ncbi.nlm.nih.gov/pubmed/28911394 https://doi.org/10.1016/j.jfda.2015.08.006 |
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ftpubmed:oai:pubmedcentral.nih.gov:9345417 2023-05-15T17:54:19+02:00 Pacific oyster-derived polysaccharides attenuate allergen-induced intestinal inflammation in a murine model of food allergy Cheng, Chiung-Hsiang Wu, Hsin-Ying Wu, Chi-Fang Jan, Tong-Rong 2015-10-16 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345417/ http://www.ncbi.nlm.nih.gov/pubmed/28911394 https://doi.org/10.1016/j.jfda.2015.08.006 en eng Taiwan Food and Drug Administration http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345417/ http://www.ncbi.nlm.nih.gov/pubmed/28911394 http://dx.doi.org/10.1016/j.jfda.2015.08.006 © 2016 Taiwan Food and Drug Administration https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). CC-BY-NC-ND J Food Drug Anal Original Article Text 2015 ftpubmed https://doi.org/10.1016/j.jfda.2015.08.006 2022-08-14T00:33:43Z Oyster-derived polysaccharides (OPS) have been shown to modulate the T helper (Th)1/Th2 immunobalance toward the Th1-dominant direction in antigen-primed splenocytes. In the present study, we hypothesized that OPS might attenuate intestinal inflammation associated with food allergy, a Th2-dominant immune disorder. BALB/c mice were sensitized twice with ovalbumin (OVA) absorbed to alum and then repeatedly challenged with intragastric OVA to induce intestinal allergic responses. The mice were administered by gavage with OPS and/or vehicle (distilled water) once/d during the two sensitization phases, and once every other day during the challenge phase. Administration with OPS attenuated OVA challenge-elicited diarrhea, and the infiltration of mast cells in the intestine. OPS demonstrated a protective effect on the reduced ratio of villus length over crypt depth of the intestine in allergic mice. Furthermore, OPS administration markedly attenuated the intestinal expression of the Th2 signature cytokine interleukin-4 (IL-4). Collectively, these results demonstrated the in vivo antiallergic activity of OPS, which is associated with the suppression of allergen-induced intestinal Th2 responses and mast cell activation. Text Pacific oyster PubMed Central (PMC) Pacific Journal of Food and Drug Analysis 24 1 121 128 |
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Original Article Cheng, Chiung-Hsiang Wu, Hsin-Ying Wu, Chi-Fang Jan, Tong-Rong Pacific oyster-derived polysaccharides attenuate allergen-induced intestinal inflammation in a murine model of food allergy |
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Original Article |
description |
Oyster-derived polysaccharides (OPS) have been shown to modulate the T helper (Th)1/Th2 immunobalance toward the Th1-dominant direction in antigen-primed splenocytes. In the present study, we hypothesized that OPS might attenuate intestinal inflammation associated with food allergy, a Th2-dominant immune disorder. BALB/c mice were sensitized twice with ovalbumin (OVA) absorbed to alum and then repeatedly challenged with intragastric OVA to induce intestinal allergic responses. The mice were administered by gavage with OPS and/or vehicle (distilled water) once/d during the two sensitization phases, and once every other day during the challenge phase. Administration with OPS attenuated OVA challenge-elicited diarrhea, and the infiltration of mast cells in the intestine. OPS demonstrated a protective effect on the reduced ratio of villus length over crypt depth of the intestine in allergic mice. Furthermore, OPS administration markedly attenuated the intestinal expression of the Th2 signature cytokine interleukin-4 (IL-4). Collectively, these results demonstrated the in vivo antiallergic activity of OPS, which is associated with the suppression of allergen-induced intestinal Th2 responses and mast cell activation. |
format |
Text |
author |
Cheng, Chiung-Hsiang Wu, Hsin-Ying Wu, Chi-Fang Jan, Tong-Rong |
author_facet |
Cheng, Chiung-Hsiang Wu, Hsin-Ying Wu, Chi-Fang Jan, Tong-Rong |
author_sort |
Cheng, Chiung-Hsiang |
title |
Pacific oyster-derived polysaccharides attenuate allergen-induced intestinal inflammation in a murine model of food allergy |
title_short |
Pacific oyster-derived polysaccharides attenuate allergen-induced intestinal inflammation in a murine model of food allergy |
title_full |
Pacific oyster-derived polysaccharides attenuate allergen-induced intestinal inflammation in a murine model of food allergy |
title_fullStr |
Pacific oyster-derived polysaccharides attenuate allergen-induced intestinal inflammation in a murine model of food allergy |
title_full_unstemmed |
Pacific oyster-derived polysaccharides attenuate allergen-induced intestinal inflammation in a murine model of food allergy |
title_sort |
pacific oyster-derived polysaccharides attenuate allergen-induced intestinal inflammation in a murine model of food allergy |
publisher |
Taiwan Food and Drug Administration |
publishDate |
2015 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345417/ http://www.ncbi.nlm.nih.gov/pubmed/28911394 https://doi.org/10.1016/j.jfda.2015.08.006 |
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Pacific |
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Pacific |
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Pacific oyster |
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Pacific oyster |
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J Food Drug Anal |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345417/ http://www.ncbi.nlm.nih.gov/pubmed/28911394 http://dx.doi.org/10.1016/j.jfda.2015.08.006 |
op_rights |
© 2016 Taiwan Food and Drug Administration https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
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CC-BY-NC-ND |
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https://doi.org/10.1016/j.jfda.2015.08.006 |
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Journal of Food and Drug Analysis |
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24 |
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1 |
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121 |
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128 |
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1766162056108572672 |