First report of successful isolation of a HPR0‐like variant of the infectious salmon anaemia virus (ISAV) using cell culture

ISAV is the causative agent of the infectious salmon anaemia (ISA), a disease listed by the OIE that has caused important economic losses to the Atlantic salmon (Salmo salar) industry. ISAV variants are identified as pathogenic or non‐pathogenic based on the presence or absence of a deletion in the...

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Bibliographic Details
Published in:Journal of Fish Diseases
Main Authors: Ditlecadet, D., Gautreau, C., Boston, L., Liston, R., Johnsen, E., Gagné, N.
Format: Text
Language:English
Published: John Wiley and Sons Inc. 2021
Subjects:
Short Communications
Atlantic salmon
Salmo salar
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299946/
http://www.ncbi.nlm.nih.gov/pubmed/34843624
https://doi.org/10.1111/jfd.13556
Description
Summary:ISAV is the causative agent of the infectious salmon anaemia (ISA), a disease listed by the OIE that has caused important economic losses to the Atlantic salmon (Salmo salar) industry. ISAV variants are identified as pathogenic or non‐pathogenic based on the presence or absence of a deletion in the highly polymorphic region (HPR) of segment 6 (S6). HPRΔ variants (pathogenic) are the only forms of the virus known to grow in cell culture. This is the first report of a HPR0 variant isolated in cell culture. The isolate is, however, atypical as it shows a marker of virulent variants on another segment (S5), which has never been reported for any other HPR0 variants. The significance of this finding remains unclear until more in‐depth work is carried out but does challenge current knowledge.

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