Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β‐Hydroxyketones
Herein we report on the development and application of chemoenzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT) of α‐substituted β‐hydroxyketones (β‐HKs), using Candida antartica lipase B (CALB) as transesterification catalyst and a ruthenium complex as epimerization catalyst. An operational...
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2021
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293354/ http://www.ncbi.nlm.nih.gov/pubmed/34428339 https://doi.org/10.1002/chem.202102683 |
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ftpubmed:oai:pubmedcentral.nih.gov:9293354 2023-05-15T14:15:45+02:00 Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β‐Hydroxyketones Hilker, Simon Posevins, Daniels Unelius, C. Rikard Bäckvall, Jan‐E. 2021-10-05 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293354/ http://www.ncbi.nlm.nih.gov/pubmed/34428339 https://doi.org/10.1002/chem.202102683 en eng John Wiley and Sons Inc. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293354/ http://www.ncbi.nlm.nih.gov/pubmed/34428339 http://dx.doi.org/10.1002/chem.202102683 © 2021 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. CC-BY Chemistry Communications Text 2021 ftpubmed https://doi.org/10.1002/chem.202102683 2022-07-31T02:04:01Z Herein we report on the development and application of chemoenzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT) of α‐substituted β‐hydroxyketones (β‐HKs), using Candida antartica lipase B (CALB) as transesterification catalyst and a ruthenium complex as epimerization catalyst. An operationally simple protocol allows for an efficient preparation of highly enantiomerically enriched α‐substituted β‐oxoacetates. The products were obtained in yields up to 95 % with good diastereomeric ratios. Text antartic* PubMed Central (PMC) Chemistry – A European Journal 27 63 15623 15627 |
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English |
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Communications |
spellingShingle |
Communications Hilker, Simon Posevins, Daniels Unelius, C. Rikard Bäckvall, Jan‐E. Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β‐Hydroxyketones |
topic_facet |
Communications |
description |
Herein we report on the development and application of chemoenzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT) of α‐substituted β‐hydroxyketones (β‐HKs), using Candida antartica lipase B (CALB) as transesterification catalyst and a ruthenium complex as epimerization catalyst. An operationally simple protocol allows for an efficient preparation of highly enantiomerically enriched α‐substituted β‐oxoacetates. The products were obtained in yields up to 95 % with good diastereomeric ratios. |
format |
Text |
author |
Hilker, Simon Posevins, Daniels Unelius, C. Rikard Bäckvall, Jan‐E. |
author_facet |
Hilker, Simon Posevins, Daniels Unelius, C. Rikard Bäckvall, Jan‐E. |
author_sort |
Hilker, Simon |
title |
Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β‐Hydroxyketones |
title_short |
Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β‐Hydroxyketones |
title_full |
Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β‐Hydroxyketones |
title_fullStr |
Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β‐Hydroxyketones |
title_full_unstemmed |
Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β‐Hydroxyketones |
title_sort |
chemoenzymatic dynamic kinetic asymmetric transformations of β‐hydroxyketones |
publisher |
John Wiley and Sons Inc. |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293354/ http://www.ncbi.nlm.nih.gov/pubmed/34428339 https://doi.org/10.1002/chem.202102683 |
genre |
antartic* |
genre_facet |
antartic* |
op_source |
Chemistry |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293354/ http://www.ncbi.nlm.nih.gov/pubmed/34428339 http://dx.doi.org/10.1002/chem.202102683 |
op_rights |
© 2021 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1002/chem.202102683 |
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Chemistry – A European Journal |
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27 |
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63 |
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15623 |
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15627 |
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1766288047292284928 |