Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β‐Hydroxyketones

Herein we report on the development and application of chemoenzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT) of α‐substituted β‐hydroxyketones (β‐HKs), using Candida antartica lipase B (CALB) as transesterification catalyst and a ruthenium complex as epimerization catalyst. An operational...

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Bibliographic Details
Published in:Chemistry – A European Journal
Main Authors: Hilker, Simon, Posevins, Daniels, Unelius, C. Rikard, Bäckvall, Jan‐E.
Format: Text
Language:English
Published: John Wiley and Sons Inc. 2021
Subjects:
Communications
antartic*
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293354/
http://www.ncbi.nlm.nih.gov/pubmed/34428339
https://doi.org/10.1002/chem.202102683
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Summary:Herein we report on the development and application of chemoenzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT) of α‐substituted β‐hydroxyketones (β‐HKs), using Candida antartica lipase B (CALB) as transesterification catalyst and a ruthenium complex as epimerization catalyst. An operationally simple protocol allows for an efficient preparation of highly enantiomerically enriched α‐substituted β‐oxoacetates. The products were obtained in yields up to 95 % with good diastereomeric ratios.

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