Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan

Streptococcus pyogenes (group A Streptococcus [GAS]) has long been regarded as being susceptible to β-lactams. However, amino acid substitutions in penicillin-binding protein 2X (PBP2X) conferring reduced in vitro β-lactam susceptibility have been indicated since 2019 in the United States and Icelan...

Full description

Bibliographic Details
Published in:Antimicrobial Agents and Chemotherapy
Main Authors: Ikeda, Tsubasa, Suzuki, Rihito, Jin, Wanchun, Wachino, Jun-ichi, Arakawa, Yoshichika, Kimura, Kouji
Format: Text
Language:English
Published: American Society for Microbiology 2021
Subjects:
Mechanisms of Resistance
Iceland
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597773/
http://www.ncbi.nlm.nih.gov/pubmed/34606335
https://doi.org/10.1128/AAC.01482-21
id ftpubmed:oai:pubmedcentral.nih.gov:8597773
record_format openpolar
spelling ftpubmed:oai:pubmedcentral.nih.gov:8597773 2023-05-15T16:48:05+02:00 Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan Ikeda, Tsubasa Suzuki, Rihito Jin, Wanchun Wachino, Jun-ichi Arakawa, Yoshichika Kimura, Kouji 2021-11-17 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597773/ http://www.ncbi.nlm.nih.gov/pubmed/34606335 https://doi.org/10.1128/AAC.01482-21 en eng American Society for Microbiology http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597773/ http://www.ncbi.nlm.nih.gov/pubmed/34606335 http://dx.doi.org/10.1128/AAC.01482-21 Copyright © 2021 American Society for Microbiology. https://doi.org/10.1128/ASMCopyrightv2All Rights Reserved (https://doi.org/10.1128/ASMCopyrightv2) . Antimicrob Agents Chemother Mechanisms of Resistance Text 2021 ftpubmed https://doi.org/10.1128/AAC.01482-21 2022-05-22T00:27:18Z Streptococcus pyogenes (group A Streptococcus [GAS]) has long been regarded as being susceptible to β-lactams. However, amino acid substitutions in penicillin-binding protein 2X (PBP2X) conferring reduced in vitro β-lactam susceptibility have been indicated since 2019 in the United States and Iceland. Here, we report the first isolation of Streptococcus pyogenes possessing the PBP2X substitution conferring reduced in vitro β-lactam susceptibility in Asia; however, the MICs were below the susceptible breakpoint of the CLSI. Text Iceland PubMed Central (PMC) Antimicrobial Agents and Chemotherapy 65 12
institution Open Polar
collection PubMed Central (PMC)
op_collection_id ftpubmed
language English
topic Mechanisms of Resistance
spellingShingle Mechanisms of Resistance
Ikeda, Tsubasa
Suzuki, Rihito
Jin, Wanchun
Wachino, Jun-ichi
Arakawa, Yoshichika
Kimura, Kouji
Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan
topic_facet Mechanisms of Resistance
description Streptococcus pyogenes (group A Streptococcus [GAS]) has long been regarded as being susceptible to β-lactams. However, amino acid substitutions in penicillin-binding protein 2X (PBP2X) conferring reduced in vitro β-lactam susceptibility have been indicated since 2019 in the United States and Iceland. Here, we report the first isolation of Streptococcus pyogenes possessing the PBP2X substitution conferring reduced in vitro β-lactam susceptibility in Asia; however, the MICs were below the susceptible breakpoint of the CLSI.
format Text
author Ikeda, Tsubasa
Suzuki, Rihito
Jin, Wanchun
Wachino, Jun-ichi
Arakawa, Yoshichika
Kimura, Kouji
author_facet Ikeda, Tsubasa
Suzuki, Rihito
Jin, Wanchun
Wachino, Jun-ichi
Arakawa, Yoshichika
Kimura, Kouji
author_sort Ikeda, Tsubasa
title Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan
title_short Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan
title_full Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan
title_fullStr Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan
title_full_unstemmed Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan
title_sort isolation of group a streptococci with reduced in vitro β-lactam susceptibility harboring amino acid substitutions in penicillin-binding proteins in japan
publisher American Society for Microbiology
publishDate 2021
url http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597773/
http://www.ncbi.nlm.nih.gov/pubmed/34606335
https://doi.org/10.1128/AAC.01482-21
genre Iceland
genre_facet Iceland
op_source Antimicrob Agents Chemother
op_relation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597773/
http://www.ncbi.nlm.nih.gov/pubmed/34606335
http://dx.doi.org/10.1128/AAC.01482-21
op_rights Copyright © 2021 American Society for Microbiology.
https://doi.org/10.1128/ASMCopyrightv2All Rights Reserved (https://doi.org/10.1128/ASMCopyrightv2) .
op_doi https://doi.org/10.1128/AAC.01482-21
container_title Antimicrobial Agents and Chemotherapy
container_volume 65
container_issue 12
_version_ 1766038212797530112

Similar Items