Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan
Streptococcus pyogenes (group A Streptococcus [GAS]) has long been regarded as being susceptible to β-lactams. However, amino acid substitutions in penicillin-binding protein 2X (PBP2X) conferring reduced in vitro β-lactam susceptibility have been indicated since 2019 in the United States and Icelan...
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American Society for Microbiology
2021
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597773/ http://www.ncbi.nlm.nih.gov/pubmed/34606335 https://doi.org/10.1128/AAC.01482-21 |
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ftpubmed:oai:pubmedcentral.nih.gov:8597773 2023-05-15T16:48:05+02:00 Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan Ikeda, Tsubasa Suzuki, Rihito Jin, Wanchun Wachino, Jun-ichi Arakawa, Yoshichika Kimura, Kouji 2021-11-17 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597773/ http://www.ncbi.nlm.nih.gov/pubmed/34606335 https://doi.org/10.1128/AAC.01482-21 en eng American Society for Microbiology http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597773/ http://www.ncbi.nlm.nih.gov/pubmed/34606335 http://dx.doi.org/10.1128/AAC.01482-21 Copyright © 2021 American Society for Microbiology. https://doi.org/10.1128/ASMCopyrightv2All Rights Reserved (https://doi.org/10.1128/ASMCopyrightv2) . Antimicrob Agents Chemother Mechanisms of Resistance Text 2021 ftpubmed https://doi.org/10.1128/AAC.01482-21 2022-05-22T00:27:18Z Streptococcus pyogenes (group A Streptococcus [GAS]) has long been regarded as being susceptible to β-lactams. However, amino acid substitutions in penicillin-binding protein 2X (PBP2X) conferring reduced in vitro β-lactam susceptibility have been indicated since 2019 in the United States and Iceland. Here, we report the first isolation of Streptococcus pyogenes possessing the PBP2X substitution conferring reduced in vitro β-lactam susceptibility in Asia; however, the MICs were below the susceptible breakpoint of the CLSI. Text Iceland PubMed Central (PMC) Antimicrobial Agents and Chemotherapy 65 12 |
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Mechanisms of Resistance |
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Mechanisms of Resistance Ikeda, Tsubasa Suzuki, Rihito Jin, Wanchun Wachino, Jun-ichi Arakawa, Yoshichika Kimura, Kouji Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan |
topic_facet |
Mechanisms of Resistance |
description |
Streptococcus pyogenes (group A Streptococcus [GAS]) has long been regarded as being susceptible to β-lactams. However, amino acid substitutions in penicillin-binding protein 2X (PBP2X) conferring reduced in vitro β-lactam susceptibility have been indicated since 2019 in the United States and Iceland. Here, we report the first isolation of Streptococcus pyogenes possessing the PBP2X substitution conferring reduced in vitro β-lactam susceptibility in Asia; however, the MICs were below the susceptible breakpoint of the CLSI. |
format |
Text |
author |
Ikeda, Tsubasa Suzuki, Rihito Jin, Wanchun Wachino, Jun-ichi Arakawa, Yoshichika Kimura, Kouji |
author_facet |
Ikeda, Tsubasa Suzuki, Rihito Jin, Wanchun Wachino, Jun-ichi Arakawa, Yoshichika Kimura, Kouji |
author_sort |
Ikeda, Tsubasa |
title |
Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan |
title_short |
Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan |
title_full |
Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan |
title_fullStr |
Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan |
title_full_unstemmed |
Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan |
title_sort |
isolation of group a streptococci with reduced in vitro β-lactam susceptibility harboring amino acid substitutions in penicillin-binding proteins in japan |
publisher |
American Society for Microbiology |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597773/ http://www.ncbi.nlm.nih.gov/pubmed/34606335 https://doi.org/10.1128/AAC.01482-21 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Antimicrob Agents Chemother |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597773/ http://www.ncbi.nlm.nih.gov/pubmed/34606335 http://dx.doi.org/10.1128/AAC.01482-21 |
op_rights |
Copyright © 2021 American Society for Microbiology. https://doi.org/10.1128/ASMCopyrightv2All Rights Reserved (https://doi.org/10.1128/ASMCopyrightv2) . |
op_doi |
https://doi.org/10.1128/AAC.01482-21 |
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Antimicrobial Agents and Chemotherapy |
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65 |
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12 |
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1766038212797530112 |