Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan

Streptococcus pyogenes (group A Streptococcus [GAS]) has long been regarded as being susceptible to β-lactams. However, amino acid substitutions in penicillin-binding protein 2X (PBP2X) conferring reduced in vitro β-lactam susceptibility have been indicated since 2019 in the United States and Icelan...

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Bibliographic Details
Published in:Antimicrobial Agents and Chemotherapy
Main Authors: Ikeda, Tsubasa, Suzuki, Rihito, Jin, Wanchun, Wachino, Jun-ichi, Arakawa, Yoshichika, Kimura, Kouji
Format: Text
Language:English
Published: American Society for Microbiology 2021
Subjects:
Mechanisms of Resistance
Iceland
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597773/
http://www.ncbi.nlm.nih.gov/pubmed/34606335
https://doi.org/10.1128/AAC.01482-21
Description
Summary:Streptococcus pyogenes (group A Streptococcus [GAS]) has long been regarded as being susceptible to β-lactams. However, amino acid substitutions in penicillin-binding protein 2X (PBP2X) conferring reduced in vitro β-lactam susceptibility have been indicated since 2019 in the United States and Iceland. Here, we report the first isolation of Streptococcus pyogenes possessing the PBP2X substitution conferring reduced in vitro β-lactam susceptibility in Asia; however, the MICs were below the susceptible breakpoint of the CLSI.

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