Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan
Streptococcus pyogenes (group A Streptococcus [GAS]) has long been regarded as being susceptible to β-lactams. However, amino acid substitutions in penicillin-binding protein 2X (PBP2X) conferring reduced in vitro β-lactam susceptibility have been indicated since 2019 in the United States and Icelan...
Published in: | Antimicrobial Agents and Chemotherapy |
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Main Authors: | , , , , , |
Format: | Text |
Language: | English |
Published: |
American Society for Microbiology
2021
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Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597773/ http://www.ncbi.nlm.nih.gov/pubmed/34606335 https://doi.org/10.1128/AAC.01482-21 |
Summary: | Streptococcus pyogenes (group A Streptococcus [GAS]) has long been regarded as being susceptible to β-lactams. However, amino acid substitutions in penicillin-binding protein 2X (PBP2X) conferring reduced in vitro β-lactam susceptibility have been indicated since 2019 in the United States and Iceland. Here, we report the first isolation of Streptococcus pyogenes possessing the PBP2X substitution conferring reduced in vitro β-lactam susceptibility in Asia; however, the MICs were below the susceptible breakpoint of the CLSI. |
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