Medetomidine- and Medetomidine-Ketamine-induced Immobilization in Blue Foxes (Alopex lagopus) and its Reversal by Atipamezole
Jalanka, H.: Medetomidine- and medetomidine-ketamine-induced immobilization in bue foxes (Alopex lagopus) and its reversal by atipamezole. Acta vet. scand. 1990, 31, 63–71. – The sedative and immobilizing effects of the alpha(2)-adrenoceptor agonist medetomidine alone or combined with the dissociati...
| Published in: | Acta Veterinaria Scandinavica |
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| Main Author: | |
| Format: | Text |
| Language: | English |
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BioMed Central
1990
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| Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133186/ http://www.ncbi.nlm.nih.gov/pubmed/1975971 https://doi.org/10.1186/BF03547578 |
| Summary: | Jalanka, H.: Medetomidine- and medetomidine-ketamine-induced immobilization in bue foxes (Alopex lagopus) and its reversal by atipamezole. Acta vet. scand. 1990, 31, 63–71. – The sedative and immobilizing effects of the alpha(2)-adrenoceptor agonist medetomidine alone or combined with the dissociative anesthetic ketamine, were studied in blue foxes. Medetomidine at doses of 25 and 50 μg/kg induced moderate to deep sedation, but only with the highest medetomidine dose tested, 100 μg/kg, was the immobilization complete. Medetomidine 50 μg/kg combined with ketamine 2.5 mg/kg rapidly induced complete immobilization, characterized by good myorelaxation, and no clinically significant alterations in serially determined hematologic and serum chemistry parameters. The alpha(2)-adrenoceptor antagonist atipamezole effectively reversed the medetomidine- or medetomidine-ketamine-induced immobilizations. A transient increase in heart rates was noted after each atipamezole injection. |
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