Primary aldosteronism: from case detection to histopathology with up to 6 years of follow‐up
The authors aimed to investigate the clinical characteristics, accuracy of diagnostic tests, and long‐term outcomes after interventions in patients diagnosed with primary aldosteronism (PA) in Iceland throughout 5 years. A retrospective chart review was performed for all patients diagnosed with PA d...
| Published in: | The Journal of Clinical Hypertension |
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| Main Authors: | , , , |
| Format: | Text |
| Language: | English |
| Published: |
John Wiley and Sons Inc.
2016
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| Subjects: | |
| Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8030871/ http://www.ncbi.nlm.nih.gov/pubmed/27878955 https://doi.org/10.1111/jch.12947 |
| Summary: | The authors aimed to investigate the clinical characteristics, accuracy of diagnostic tests, and long‐term outcomes after interventions in patients diagnosed with primary aldosteronism (PA) in Iceland throughout 5 years. A retrospective chart review was performed for all patients diagnosed with PA during the years 2007–2011 at Landspitali Hospital in Iceland, a referral center for the whole country. Workup after detection included salt loading test, positional test, computed tomography, and adrenal vein sampling. Patients with unilateral disease were offered treatment with adrenalectomy. A total of 33 patients were diagnosed with PA during the study period: 17 patients with bilateral disease and 16 with unilateral disease. Results from salt loading test were positive in 90% of patients. In patients with adenoma, 36% were responsive on their positional test and computed tomography scan showed a nodule in 73%. All patients with unilateral disease had a lateralization index ≥3. After surgery, patients had lower systolic blood pressure (P<.001) and number of hypertensive medications (P<.01). |
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