Cylindromicin from Arctic-Derived Fungus Tolypocladium sp. SCSIO 40433

The fungus strain SCSIO 40433 was isolated from an Arctic-derived glacier sediment sample and characterized as Tolypocladium cylindrosporum. A new compound, cylindromicin (1), and seven known secondary metabolites (2–8) were isolated from this strain. The chemical structures of these compounds were...

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Bibliographic Details
Published in:Molecules
Main Authors: Khan, Imran, Peng, Jing, Fang, Zhuangjie, Liu, Wei, Zhang, Wenjun, Zhang, Qingbo, Ma, Liang, Zhang, Guangtao, Zhang, Changsheng, Zhang, Haibo
Format: Text
Language:English
Published: MDPI 2021
Subjects:
Article
Arctic
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922244/
https://doi.org/10.3390/molecules26041080
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Summary:The fungus strain SCSIO 40433 was isolated from an Arctic-derived glacier sediment sample and characterized as Tolypocladium cylindrosporum. A new compound, cylindromicin (1), and seven known secondary metabolites (2–8) were isolated from this strain. The chemical structures of these compounds were elucidated by comprehensive spectroscopic analyses. Cylindromicin (1) featured a 3,4-dihydro-2H-pyran skeleton. The absolute configuration of compound 1 was assigned via interpretation of key Nuclear Overhauser Effect Spectroscopy (NOESY) correlations and Electronic Circular Dichroism (ECD) calculation. Cylindromicin (1) exhibited significant tyrosinase inhibition activity. This study highlights Polar fungi as a potential resource for new bioactive natural products.

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