The FEV(1)/FEV(6) ratio is a good substitute for the FEV(1)/FVC ratio in the elderly

AIMS: To determine the agreement between the FEV(1)/FEV(6) ratio and the FEV(1)/FVC ratio in an elderly population. METHOD: The study sample consisted of 3874 participants in a cross-sectional population survey in Tromso¨, Norway, aged 60 years or more, in whom acceptable spirometry had been obtaine...

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Bibliographic Details
Published in:Primary Care Respiratory Journal
Main Authors: Melbye, Hasse, Medbø, Astri, Crockett, Alan
Format: Text
Language:English
Published: Nature Publishing Group 2006
Subjects:
Original Research
Norway
Tromso
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730822/
http://www.ncbi.nlm.nih.gov/pubmed/16979378
https://doi.org/10.1016/j.pcrj.2006.07.002
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Summary:AIMS: To determine the agreement between the FEV(1)/FEV(6) ratio and the FEV(1)/FVC ratio in an elderly population. METHOD: The study sample consisted of 3874 participants in a cross-sectional population survey in Tromso¨, Norway, aged 60 years or more, in whom acceptable spirometry had been obtained. Mean differences between the FEV(1)/FEV(6) ratio (%) and the FEV(1)/FVC ratio (%) were calculated according to age, sex, smoking habit, and the degree of airflow limitation. ROC-curve analysis and Kappa-statistics were used to estimate the utility of the FEV(1)/FEV(6) ratio in predicting an FEV(1)/FVC ratio< 70%. RESULTS: The mean difference between FEV(1)/FEV(6)% and FEV(1)/FVC% was 2.7% in both men and women. The difference between the two measures increased somewhat with increasing age, and was more pronounced with smoking and decreasing FEV(1)/FVC ratio. The value for the FEV(1)/FEV(6) ratio which best predicted an FEV(1)/FVC ratio of 70%, was 73%, and a very good agreement was found between these two cutoff values (kappa = 0.86). CONCLUSION: The FEV(1)/FEV(6) ratio appears to be a good substitute for the FEV(1)/FVC ratio in an elderly population.

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