Study of correlation between the NAT2 phenotype and genotype status among Greenlandic Inuit

N-acetyltransferase 2 (NAT2) is the main enzyme metabolizing isoniazid and genotype-based treatment has been studied for years without becoming common practice. To investigate whether genotype-based isoniazid treatment is feasible in Greenland, we sequenced the coding sequence of NAT2 and determined...

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Main Authors: Birch Kristensen, Emilie, Yakimov, Victor, Bjorn-Mortensen, Karen, Soborg, Bolette, Koch, Anders, Andersson, Mikael, Birch Kristensen, Kasper, Michelsen, Sascha Wilk, Skotte, Line, Ahrendt Bjerregaard, Anne, Blaszkewicz, Meinolf, Golka, Klaus, Hengstler, Jan G., Feenstra, Bjarke, Melbye, Mads, Geller, Frank
Format: Text
Language:English
Published: Leibniz Research Centre for Working Environment and Human Factors 2018
Subjects:
Original Article
Greenland
greenlandic
inuit
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295636/
http://www.ncbi.nlm.nih.gov/pubmed/30564082
https://doi.org/10.17179/excli2018-1671
id ftpubmed:oai:pubmedcentral.nih.gov:6295636
record_format openpolar
spelling ftpubmed:oai:pubmedcentral.nih.gov:6295636 2023-05-15T16:27:20+02:00 Study of correlation between the NAT2 phenotype and genotype status among Greenlandic Inuit Birch Kristensen, Emilie Yakimov, Victor Bjorn-Mortensen, Karen Soborg, Bolette Koch, Anders Andersson, Mikael Birch Kristensen, Kasper Michelsen, Sascha Wilk Skotte, Line Ahrendt Bjerregaard, Anne Blaszkewicz, Meinolf Golka, Klaus Hengstler, Jan G. Feenstra, Bjarke Melbye, Mads Geller, Frank 2018-11-02 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295636/ http://www.ncbi.nlm.nih.gov/pubmed/30564082 https://doi.org/10.17179/excli2018-1671 en eng Leibniz Research Centre for Working Environment and Human Factors http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295636/ http://www.ncbi.nlm.nih.gov/pubmed/30564082 http://dx.doi.org/10.17179/excli2018-1671 Copyright © 2018 Birch Kristensen et al. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/) You are free to copy, distribute and transmit the work, provided the original author and source are credited. CC-BY Original Article Text 2018 ftpubmed https://doi.org/10.17179/excli2018-1671 2018-12-23T01:28:55Z N-acetyltransferase 2 (NAT2) is the main enzyme metabolizing isoniazid and genotype-based treatment has been studied for years without becoming common practice. To investigate whether genotype-based isoniazid treatment is feasible in Greenland, we sequenced the coding sequence of NAT2 and determined the NAT2 enzyme-activity by caffeine test. Text Greenland greenlandic inuit PubMed Central (PMC) Greenland
institution Open Polar
collection PubMed Central (PMC)
op_collection_id ftpubmed
language English
topic Original Article
spellingShingle Original Article
Birch Kristensen, Emilie
Yakimov, Victor
Bjorn-Mortensen, Karen
Soborg, Bolette
Koch, Anders
Andersson, Mikael
Birch Kristensen, Kasper
Michelsen, Sascha Wilk
Skotte, Line
Ahrendt Bjerregaard, Anne
Blaszkewicz, Meinolf
Golka, Klaus
Hengstler, Jan G.
Feenstra, Bjarke
Melbye, Mads
Geller, Frank
Study of correlation between the NAT2 phenotype and genotype status among Greenlandic Inuit
topic_facet Original Article
description N-acetyltransferase 2 (NAT2) is the main enzyme metabolizing isoniazid and genotype-based treatment has been studied for years without becoming common practice. To investigate whether genotype-based isoniazid treatment is feasible in Greenland, we sequenced the coding sequence of NAT2 and determined the NAT2 enzyme-activity by caffeine test.
format Text
author Birch Kristensen, Emilie
Yakimov, Victor
Bjorn-Mortensen, Karen
Soborg, Bolette
Koch, Anders
Andersson, Mikael
Birch Kristensen, Kasper
Michelsen, Sascha Wilk
Skotte, Line
Ahrendt Bjerregaard, Anne
Blaszkewicz, Meinolf
Golka, Klaus
Hengstler, Jan G.
Feenstra, Bjarke
Melbye, Mads
Geller, Frank
author_facet Birch Kristensen, Emilie
Yakimov, Victor
Bjorn-Mortensen, Karen
Soborg, Bolette
Koch, Anders
Andersson, Mikael
Birch Kristensen, Kasper
Michelsen, Sascha Wilk
Skotte, Line
Ahrendt Bjerregaard, Anne
Blaszkewicz, Meinolf
Golka, Klaus
Hengstler, Jan G.
Feenstra, Bjarke
Melbye, Mads
Geller, Frank
author_sort Birch Kristensen, Emilie
title Study of correlation between the NAT2 phenotype and genotype status among Greenlandic Inuit
title_short Study of correlation between the NAT2 phenotype and genotype status among Greenlandic Inuit
title_full Study of correlation between the NAT2 phenotype and genotype status among Greenlandic Inuit
title_fullStr Study of correlation between the NAT2 phenotype and genotype status among Greenlandic Inuit
title_full_unstemmed Study of correlation between the NAT2 phenotype and genotype status among Greenlandic Inuit
title_sort study of correlation between the nat2 phenotype and genotype status among greenlandic inuit
publisher Leibniz Research Centre for Working Environment and Human Factors
publishDate 2018
url http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295636/
http://www.ncbi.nlm.nih.gov/pubmed/30564082
https://doi.org/10.17179/excli2018-1671
geographic Greenland
geographic_facet Greenland
genre Greenland
greenlandic
inuit
genre_facet Greenland
greenlandic
inuit
op_relation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295636/
http://www.ncbi.nlm.nih.gov/pubmed/30564082
http://dx.doi.org/10.17179/excli2018-1671
op_rights Copyright © 2018 Birch Kristensen et al.
http://creativecommons.org/licenses/by/4.0/
This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/) You are free to copy, distribute and transmit the work, provided the original author and source are credited.
op_rightsnorm CC-BY
op_doi https://doi.org/10.17179/excli2018-1671
_version_ 1766016477969776640

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