Study of correlation between the NAT2 phenotype and genotype status among Greenlandic Inuit
N-acetyltransferase 2 (NAT2) is the main enzyme metabolizing isoniazid and genotype-based treatment has been studied for years without becoming common practice. To investigate whether genotype-based isoniazid treatment is feasible in Greenland, we sequenced the coding sequence of NAT2 and determined...
Main Authors: | , , , , , , , , , , , , , , , |
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Format: | Text |
Language: | English |
Published: |
Leibniz Research Centre for Working Environment and Human Factors
2018
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Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295636/ http://www.ncbi.nlm.nih.gov/pubmed/30564082 https://doi.org/10.17179/excli2018-1671 |
Summary: | N-acetyltransferase 2 (NAT2) is the main enzyme metabolizing isoniazid and genotype-based treatment has been studied for years without becoming common practice. To investigate whether genotype-based isoniazid treatment is feasible in Greenland, we sequenced the coding sequence of NAT2 and determined the NAT2 enzyme-activity by caffeine test. |
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