Study of correlation between the NAT2 phenotype and genotype status among Greenlandic Inuit

N-acetyltransferase 2 (NAT2) is the main enzyme metabolizing isoniazid and genotype-based treatment has been studied for years without becoming common practice. To investigate whether genotype-based isoniazid treatment is feasible in Greenland, we sequenced the coding sequence of NAT2 and determined...

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Bibliographic Details
Main Authors: Birch Kristensen, Emilie, Yakimov, Victor, Bjorn-Mortensen, Karen, Soborg, Bolette, Koch, Anders, Andersson, Mikael, Birch Kristensen, Kasper, Michelsen, Sascha Wilk, Skotte, Line, Ahrendt Bjerregaard, Anne, Blaszkewicz, Meinolf, Golka, Klaus, Hengstler, Jan G., Feenstra, Bjarke, Melbye, Mads, Geller, Frank
Format: Text
Language:English
Published: Leibniz Research Centre for Working Environment and Human Factors 2018
Subjects:
Original Article
Greenland
greenlandic
inuit
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295636/
http://www.ncbi.nlm.nih.gov/pubmed/30564082
https://doi.org/10.17179/excli2018-1671
Description
Summary:N-acetyltransferase 2 (NAT2) is the main enzyme metabolizing isoniazid and genotype-based treatment has been studied for years without becoming common practice. To investigate whether genotype-based isoniazid treatment is feasible in Greenland, we sequenced the coding sequence of NAT2 and determined the NAT2 enzyme-activity by caffeine test.

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