Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment

Antartin (1), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the abs...

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Bibliographic Details
Published in:Marine Drugs
Main Authors: Kim, Dayoung, Lee, Eun Ju, Lee, Jihye, Leutou, Alain S., Shin, Yern-Hyerk, Choi, Bomi, Hwang, Ji Sun, Hahn, Dongyup, Choi, Hyukjae, Chin, Jungwook, Cho, Sung Jin, Hong, Yong Deog, Ko, Jaeyoung, Seong, Chi Nam, Maloney, Katherine N., Oh, Dong-Chan, Yang, Inho, Hwang, Hayoung, Nam, Sang-Jip
Format: Text
Language:English
Published: MDPI 2018
Subjects:
Article
Antarctic
Antarc*
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923417/
http://www.ncbi.nlm.nih.gov/pubmed/29659509
https://doi.org/10.3390/md16040130
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Summary:Antartin (1), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the absolute stereochemistry was decided based on a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Antartin (1) showed cytotoxicity against A549, H1299, and U87 cancer cell lines by causing cell cycle arrest at the G1 phase.

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