Using ancient DNA and coalescent-based methods to infer extinction

DNA sequences extracted from preserved remains can add considerable resolution to inference of past population dynamics. For example, coalescent-based methods have been used to correlate declines in some arctic megafauna populations with habitat fragmentation during the last ice age. These methods,...

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Bibliographic Details
Published in:Biology Letters
Main Authors: Chang, Dan, Shapiro, Beth
Format: Text
Language:English
Published: The Royal Society 2016
Subjects:
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780543/
http://www.ncbi.nlm.nih.gov/pubmed/26864783
https://doi.org/10.1098/rsbl.2015.0822
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Summary:DNA sequences extracted from preserved remains can add considerable resolution to inference of past population dynamics. For example, coalescent-based methods have been used to correlate declines in some arctic megafauna populations with habitat fragmentation during the last ice age. These methods, however, often fail to detect population declines preceding extinction, most likely owing to a combination of sparse sampling, uninformative genetic markers, and models that cannot account for the increasingly structured nature of populations as habitats decline. As ancient DNA research expands to include full-genome analyses, these data will provide greater resolution of the genomic consequences of environmental change and the genetic signatures of extinction.