Hepatitis B among Inuit: A review with focus on Greenland Inuit

Hepatitis B virus (HBV) infection is a disease with a highly variable course. Chronic HBV infection may cause end-stage liver disease including cirrhosis and hepatocellular carcinoma, which is the 3rd most common cause of cancer related death due to the poor prognosis. The prevalence of HBV infectio...

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Bibliographic Details
Published in:World Journal of Hepatology
Main Authors: Rex, Karsten Fleischer, Andersen, Stig, Krarup, Henrik Bygum
Format: Text
Language:English
Published: Baishideng Publishing Group Inc 2015
Subjects:
Minireviews
Arctic
Canada
Greenland
inuit
Alaska
Siberia
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438501/
http://www.ncbi.nlm.nih.gov/pubmed/26019742
https://doi.org/10.4254/wjh.v7.i9.1265
Description
Summary:Hepatitis B virus (HBV) infection is a disease with a highly variable course. Chronic HBV infection may cause end-stage liver disease including cirrhosis and hepatocellular carcinoma, which is the 3rd most common cause of cancer related death due to the poor prognosis. The prevalence of HBV infection is low in many countries. Still, it remains important due to the potential consequences of the disease. HBV is endemic in the Arctic with serologic markers of chronic HBV infection in up to 29% of the population in some areas in Greenland. Interestingly, Inuit populations rarely show signs of liver disease despite the fact that around half of all Inuit has been exposed to HBV and around 8% of Inuit are chronically infected with HBV. These findings have been consistent in surveys conducted for more than four decades among Arctic Inuit. We thus review HBV infection in the Arctic with focus on Greenland Inuit and compared with Inuit in Canada, Alaska and Siberia. The aspects described include epidemiology and monitoring of the disease, as well as treatment and the risk of liver cancer.

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