Serum Phthalate Levels and Time to Pregnancy in Couples from Greenland, Poland and Ukraine

Phthalates are ubiquitous industrial chemicals that have been associated with altered reproductive function in rodents. Several human studies have reported an inverse association between male testosterone and phthalate levels. Our aim was to investigate time to pregnancy (TTP) according to serum lev...

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Bibliographic Details
Published in:PLOS ONE
Main Authors: Specht, Ina Olmer, Bonde, Jens Peter, Toft, Gunnar, Lindh, Christian H., Jönsson, Bo A. G., Jørgensen, Kristian T.
Format: Text
Language:English
Published: Public Library of Science 2015
Subjects:
Research Article
Greenland
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364890
http://www.ncbi.nlm.nih.gov/pubmed/25786246
https://doi.org/10.1371/journal.pone.0120070
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Summary:Phthalates are ubiquitous industrial chemicals that have been associated with altered reproductive function in rodents. Several human studies have reported an inverse association between male testosterone and phthalate levels. Our aim was to investigate time to pregnancy (TTP) according to serum levels of diethylhexyl phthalate (DEHP) and diisononyl phthalate (DiNP) metabolites in both partners. In 2002-2004 we enrolled 938 pregnant women and 401 male spouses from Greenland, Poland and Ukraine. Six oxidized metabolites of DEHP and DiNP were summarized for each of the two parent compounds to provide proxies of the internal exposure. We used Cox discrete-time models to estimate fecundability ratios (FR) and 95% confidence intervals (95% CIs) for men and women according to their proxy-DEHP or -DiNP serum levels adjusted for a fixed set of covariates.

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