Shagenes A and B, New Tricyclic Sesquiterpenes Produced by an Undescribed Antarctic Octocoral

The isolation and characterization of two new tricyclic sesquiterpenoids, shagenes A (1) and B (2) are presented. These compounds were isolated from an undescribed soft coral collected from the Scotia Arc in the Southern Ocean. One- and two-dimensional NMR spectroscopy and mass spectrometry provided...

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Bibliographic Details
Published in:Organic Letters
Main Authors: von Salm, Jacqueline L., Wilson, Nerida G., Vesely, Brian A., Kyle, Dennis E., Cuce, Jason, Baker, Bill J.
Format: Text
Language:English
Published: 2014
Subjects:
Article
Antarctic
Southern Ocean
Antarc*
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127331/
http://www.ncbi.nlm.nih.gov/pubmed/24779517
https://doi.org/10.1021/ol500792x
Description
Summary:The isolation and characterization of two new tricyclic sesquiterpenoids, shagenes A (1) and B (2) are presented. These compounds were isolated from an undescribed soft coral collected from the Scotia Arc in the Southern Ocean. One- and two-dimensional NMR spectroscopy and mass spectrometry provided the data necessary to characterize the compounds and their relative stereochemical configurations. Exploration of the bioactivity of shagenes A and B found 1 active against the visceral leishmaniasis causing parasite, Leishmania donovani, with no cytotoxicity against the mammalian host.

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