Coronary artery calcium distributions in older persons in the AGES-Reykjavik study

Coronary Artery Calcium (CAC) is a sign of advanced atherosclerosis and an independent risk factor for cardiac events. Here, we describe CAC-distributions in an unselected aged population and compare modelling methods to characterize CAC-distribution. CAC is difficult to model because it has a skewe...

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Bibliographic Details
Published in:European Journal of Epidemiology
Main Authors: Gudmundsson, Elias Freyr, Gudnason, Vilmundur, Sigurdsson, Sigurdur, Launer, Lenore J., Harris, Tamara B., Aspelund, Thor
Format: Text
Language:English
Published: 2012
Subjects:
Article
Iceland
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746182
http://www.ncbi.nlm.nih.gov/pubmed/22990371
https://doi.org/10.1007/s10654-012-9730-6
Description
Summary:Coronary Artery Calcium (CAC) is a sign of advanced atherosclerosis and an independent risk factor for cardiac events. Here, we describe CAC-distributions in an unselected aged population and compare modelling methods to characterize CAC-distribution. CAC is difficult to model because it has a skewed and zero inflated distribution with over-dispersion. Data are from the AGES-Reykjavik sample, a large population based study [2002-2006] in Iceland of 5,764 persons aged 66-96 years.

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