Enzymatic synthesis of N-Acylethanolamines: Direct method for the aminolysis of esters

Immobilized Candida antarctica (Novozyme 435) catalyzed synthesis of N-acylethanolamines is described. Treatment of methyl esters with lipase and amines yielded the desired amides within 2–24 hrs with yields ranging from 41–98%.

Bibliographic Details
Published in:Tetrahedron Letters
Main Authors: Whitten, Kyle M., Makriyannis, Alexandros, Vadivel, Subramanian K.
Format: Text
Language:English
Published: 2012
Subjects:
Article
Antarc*
Antarctica
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500964
http://www.ncbi.nlm.nih.gov/pubmed/23175586
https://doi.org/10.1016/j.tetlet.2012.08.042
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spelling ftpubmed:oai:pubmedcentral.nih.gov:3500964 2023-05-15T13:46:21+02:00 Enzymatic synthesis of N-Acylethanolamines: Direct method for the aminolysis of esters Whitten, Kyle M. Makriyannis, Alexandros Vadivel, Subramanian K. 2012-08-18 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500964 http://www.ncbi.nlm.nih.gov/pubmed/23175586 https://doi.org/10.1016/j.tetlet.2012.08.042 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500964 http://www.ncbi.nlm.nih.gov/pubmed/23175586 http://dx.doi.org/10.1016/j.tetlet.2012.08.042 © 2012 Elsevier Ltd. All rights reserved Article Text 2012 ftpubmed https://doi.org/10.1016/j.tetlet.2012.08.042 2013-10-27T00:22:27Z Immobilized Candida antarctica (Novozyme 435) catalyzed synthesis of N-acylethanolamines is described. Treatment of methyl esters with lipase and amines yielded the desired amides within 2–24 hrs with yields ranging from 41–98%. Text Antarc* Antarctica PubMed Central (PMC) Tetrahedron Letters 53 43 5753 5755
institution Open Polar
collection PubMed Central (PMC)
op_collection_id ftpubmed
language English
topic Article
spellingShingle Article
Whitten, Kyle M.
Makriyannis, Alexandros
Vadivel, Subramanian K.
Enzymatic synthesis of N-Acylethanolamines: Direct method for the aminolysis of esters
topic_facet Article
description Immobilized Candida antarctica (Novozyme 435) catalyzed synthesis of N-acylethanolamines is described. Treatment of methyl esters with lipase and amines yielded the desired amides within 2–24 hrs with yields ranging from 41–98%.
format Text
author Whitten, Kyle M.
Makriyannis, Alexandros
Vadivel, Subramanian K.
author_facet Whitten, Kyle M.
Makriyannis, Alexandros
Vadivel, Subramanian K.
author_sort Whitten, Kyle M.
title Enzymatic synthesis of N-Acylethanolamines: Direct method for the aminolysis of esters
title_short Enzymatic synthesis of N-Acylethanolamines: Direct method for the aminolysis of esters
title_full Enzymatic synthesis of N-Acylethanolamines: Direct method for the aminolysis of esters
title_fullStr Enzymatic synthesis of N-Acylethanolamines: Direct method for the aminolysis of esters
title_full_unstemmed Enzymatic synthesis of N-Acylethanolamines: Direct method for the aminolysis of esters
title_sort enzymatic synthesis of n-acylethanolamines: direct method for the aminolysis of esters
publishDate 2012
url http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500964
http://www.ncbi.nlm.nih.gov/pubmed/23175586
https://doi.org/10.1016/j.tetlet.2012.08.042
genre Antarc*
Antarctica
genre_facet Antarc*
Antarctica
op_relation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500964
http://www.ncbi.nlm.nih.gov/pubmed/23175586
http://dx.doi.org/10.1016/j.tetlet.2012.08.042
op_rights © 2012 Elsevier Ltd. All rights reserved
op_doi https://doi.org/10.1016/j.tetlet.2012.08.042
container_title Tetrahedron Letters
container_volume 53
container_issue 43
container_start_page 5753
op_container_end_page 5755
_version_ 1766240700830056448

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