Enzymatic synthesis of N-Acylethanolamines: Direct method for the aminolysis of esters

Immobilized Candida antarctica (Novozyme 435) catalyzed synthesis of N-acylethanolamines is described. Treatment of methyl esters with lipase and amines yielded the desired amides within 2–24 hrs with yields ranging from 41–98%.

Bibliographic Details
Published in:Tetrahedron Letters
Main Authors: Whitten, Kyle M., Makriyannis, Alexandros, Vadivel, Subramanian K.
Format: Text
Language:English
Published: 2012
Subjects:
Article
Antarc*
Antarctica
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500964
http://www.ncbi.nlm.nih.gov/pubmed/23175586
https://doi.org/10.1016/j.tetlet.2012.08.042
Description
Summary:Immobilized Candida antarctica (Novozyme 435) catalyzed synthesis of N-acylethanolamines is described. Treatment of methyl esters with lipase and amines yielded the desired amides within 2–24 hrs with yields ranging from 41–98%.

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