Enzymatic synthesis of N-Acylethanolamines: Direct method for the aminolysis of esters
Immobilized Candida antarctica (Novozyme 435) catalyzed synthesis of N-acylethanolamines is described. Treatment of methyl esters with lipase and amines yielded the desired amides within 2–24 hrs with yields ranging from 41–98%.
Published in: | Tetrahedron Letters |
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Main Authors: | , , |
Format: | Text |
Language: | English |
Published: |
2012
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Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500964 http://www.ncbi.nlm.nih.gov/pubmed/23175586 https://doi.org/10.1016/j.tetlet.2012.08.042 |
Summary: | Immobilized Candida antarctica (Novozyme 435) catalyzed synthesis of N-acylethanolamines is described. Treatment of methyl esters with lipase and amines yielded the desired amides within 2–24 hrs with yields ranging from 41–98%. |
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