Organic Radical Contrast Agents for Magnetic Resonance Imaging

We report a molecular design that provides an intravenously injectable organic radical contrast agent (ORCA) that has molecular r1 ≈ 5 mM−1s−1. The ORCA is based on spirocyclohexyl nitroxide radicals and polyethylene glycol chains conjugated to a generation 4 polypropylenimine dendrimers scaffold. T...

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Bibliographic Details
Published in:Journal of the American Chemical Society
Main Authors: Rajca, Andrzej, Wang, Ying, Boska, Michael, Paletta, Joseph T., Olankitwanit, Arnon, Swanson, Michael A., Mitchell, Deborah G., Eaton, Sandra S., Eaton, Gareth R., Rajca, Suchada
Format: Text
Language:English
Published: 2012
Subjects:
Article
Orca
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486519
http://www.ncbi.nlm.nih.gov/pubmed/22974177
https://doi.org/10.1021/ja3079829
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Summary:We report a molecular design that provides an intravenously injectable organic radical contrast agent (ORCA) that has molecular r1 ≈ 5 mM−1s−1. The ORCA is based on spirocyclohexyl nitroxide radicals and polyethylene glycol chains conjugated to a generation 4 polypropylenimine dendrimers scaffold. The metal-free ORCA has a long shelf-life and provides selectively enhanced MRI in mice for over 1 h.

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