Pleiotropic effects on subclasses of HDL, adiposity and glucose metabolism in adult Alaskan Eskimos

The aim of the present study was to analyze the heritability and the presence of pleiotropic effects on subfractions of high density lipoproteins (HDLs) as measured by nuclear magnetic resonance (NMR), parameters for adiposity and glucose metabolism in adult Alaskan Eskimos. The present family study...

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Bibliographic Details
Published in:American Journal of Human Biology
Main Authors: Tejero, ME, Voruganti, VS, Cai, G, Cole, SA, Laston, S, Wenger, CR, MacCluer, JW, Dyke, B, Devereux, R, Ebbesson, SO, Fabsitz, RR, Howard, BV, Comuzzie, AG
Format: Text
Language:English
Published: 2010
Subjects:
Article
eskimo*
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461838
http://www.ncbi.nlm.nih.gov/pubmed/19950191
https://doi.org/10.1002/ajhb.21015
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Summary:The aim of the present study was to analyze the heritability and the presence of pleiotropic effects on subfractions of high density lipoproteins (HDLs) as measured by nuclear magnetic resonance (NMR), parameters for adiposity and glucose metabolism in adult Alaskan Eskimos. The present family study included 1214 adult Alaskan Eskimos (537 male/677 female). Body weight, height, circumferences, selected skinfolds and blood pressure were measured in all participants. Blood samples were collected under fasting conditions for isolation of plasma. Glucose, insulin, subclasses and size of lipoproteins, triglycerides, total and HDL cholesterol and lipoprotein (a) were measured in plasma. HbA1c was measured in total blood. Univariate and bivariate quantitative genetic analyses were conducted between HDL subclasses and size and the anthropometric and biochemical measures using the variance decomposition approach. Variation in all the analyzed traits exhibits a significant genetic component. Heritabilities ranged between 0.18 ± 0.11 for LDL2 (intermediate) to 0.89 ± 0.07 for small HDL. No common genetic effects were found on the HDL subclasses (small, intermediate and large). Small HDL particles were genetically correlated with LDL particles and HbA1c. Negative genetic correlations were observed between intermediate and large HDL subfractions and HDL size and measures of adiposity, LDL and parameters for glucose metabolism (HbA1, insulin). These observations confirm the presence of possible pleiotropic effects on HDL, adiposity and cardiovascular risk factors and provide novel insight on the relationship between HDL subclasses, adiposity and glucose regulation.

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