SRY-positive 78, XY ovotesticular disorder of sex development in a wolf cloned by nuclear transfer

Recently, we reported the three wolves cloning with normal karyotype from somatic cells of endangered male gray wolves (Canis lupus), but one wolf had female external genitalia. In this study, we conducted further clinical, histological, and genetic analyses. This cloned wolf had a normal uterus but...

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Published in:Journal of Veterinary Science
Main Authors: Kang, Jung Taek, Kim, Hyung Jin, Oh, Hyun Ju, Hong, So Gun, Park, Jung Eun, Kim, Min Jung, Kim, Min Kyu, Jang, Goo, Kim, Dae Yong, Lee, Byeong Chun
Format: Text
Language:English
Published: The Korean Society of Veterinary Science 2012
Subjects:
Case Report
Canis lupus
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386349
http://www.ncbi.nlm.nih.gov/pubmed/22705746
https://doi.org/10.4142/jvs.2012.13.2.211
id ftpubmed:oai:pubmedcentral.nih.gov:3386349
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spelling ftpubmed:oai:pubmedcentral.nih.gov:3386349 2023-05-15T15:49:52+02:00 SRY-positive 78, XY ovotesticular disorder of sex development in a wolf cloned by nuclear transfer Kang, Jung Taek Kim, Hyung Jin Oh, Hyun Ju Hong, So Gun Park, Jung Eun Kim, Min Jung Kim, Min Kyu Jang, Goo Kim, Dae Yong Lee, Byeong Chun 2012-06 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386349 http://www.ncbi.nlm.nih.gov/pubmed/22705746 https://doi.org/10.4142/jvs.2012.13.2.211 en eng The Korean Society of Veterinary Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386349 http://www.ncbi.nlm.nih.gov/pubmed/22705746 http://dx.doi.org/10.4142/jvs.2012.13.2.211 © 2012 The Korean Society of Veterinary Science. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY-NC Case Report Text 2012 ftpubmed https://doi.org/10.4142/jvs.2012.13.2.211 2013-09-04T09:26:56Z Recently, we reported the three wolves cloning with normal karyotype from somatic cells of endangered male gray wolves (Canis lupus), but one wolf had female external genitalia. In this study, we conducted further clinical, histological, and genetic analyses. This cloned wolf had a normal uterus but developed ovotestis. Through molecular analysis of the SRY gene, a mutation in the coding sequence of SRY gene could be excluded as a cause of intersexuality. This is the first report of a cloned wolf with a 78, XY ovotesticular disorder affecting sexual development characterized by bilateral ovotestes. Text Canis lupus PubMed Central (PMC) Journal of Veterinary Science 13 2 211
institution Open Polar
collection PubMed Central (PMC)
op_collection_id ftpubmed
language English
topic Case Report
spellingShingle Case Report
Kang, Jung Taek
Kim, Hyung Jin
Oh, Hyun Ju
Hong, So Gun
Park, Jung Eun
Kim, Min Jung
Kim, Min Kyu
Jang, Goo
Kim, Dae Yong
Lee, Byeong Chun
SRY-positive 78, XY ovotesticular disorder of sex development in a wolf cloned by nuclear transfer
topic_facet Case Report
description Recently, we reported the three wolves cloning with normal karyotype from somatic cells of endangered male gray wolves (Canis lupus), but one wolf had female external genitalia. In this study, we conducted further clinical, histological, and genetic analyses. This cloned wolf had a normal uterus but developed ovotestis. Through molecular analysis of the SRY gene, a mutation in the coding sequence of SRY gene could be excluded as a cause of intersexuality. This is the first report of a cloned wolf with a 78, XY ovotesticular disorder affecting sexual development characterized by bilateral ovotestes.
format Text
author Kang, Jung Taek
Kim, Hyung Jin
Oh, Hyun Ju
Hong, So Gun
Park, Jung Eun
Kim, Min Jung
Kim, Min Kyu
Jang, Goo
Kim, Dae Yong
Lee, Byeong Chun
author_facet Kang, Jung Taek
Kim, Hyung Jin
Oh, Hyun Ju
Hong, So Gun
Park, Jung Eun
Kim, Min Jung
Kim, Min Kyu
Jang, Goo
Kim, Dae Yong
Lee, Byeong Chun
author_sort Kang, Jung Taek
title SRY-positive 78, XY ovotesticular disorder of sex development in a wolf cloned by nuclear transfer
title_short SRY-positive 78, XY ovotesticular disorder of sex development in a wolf cloned by nuclear transfer
title_full SRY-positive 78, XY ovotesticular disorder of sex development in a wolf cloned by nuclear transfer
title_fullStr SRY-positive 78, XY ovotesticular disorder of sex development in a wolf cloned by nuclear transfer
title_full_unstemmed SRY-positive 78, XY ovotesticular disorder of sex development in a wolf cloned by nuclear transfer
title_sort sry-positive 78, xy ovotesticular disorder of sex development in a wolf cloned by nuclear transfer
publisher The Korean Society of Veterinary Science
publishDate 2012
url http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386349
http://www.ncbi.nlm.nih.gov/pubmed/22705746
https://doi.org/10.4142/jvs.2012.13.2.211
genre Canis lupus
genre_facet Canis lupus
op_relation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386349
http://www.ncbi.nlm.nih.gov/pubmed/22705746
http://dx.doi.org/10.4142/jvs.2012.13.2.211
op_rights © 2012 The Korean Society of Veterinary Science.
http://creativecommons.org/licenses/by-nc/3.0
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
op_rightsnorm CC-BY-NC
op_doi https://doi.org/10.4142/jvs.2012.13.2.211
container_title Journal of Veterinary Science
container_volume 13
container_issue 2
container_start_page 211
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