SRY-positive 78, XY ovotesticular disorder of sex development in a wolf cloned by nuclear transfer

Recently, we reported the three wolves cloning with normal karyotype from somatic cells of endangered male gray wolves (Canis lupus), but one wolf had female external genitalia. In this study, we conducted further clinical, histological, and genetic analyses. This cloned wolf had a normal uterus but...

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Bibliographic Details
Published in:Journal of Veterinary Science
Main Authors: Kang, Jung Taek, Kim, Hyung Jin, Oh, Hyun Ju, Hong, So Gun, Park, Jung Eun, Kim, Min Jung, Kim, Min Kyu, Jang, Goo, Kim, Dae Yong, Lee, Byeong Chun
Format: Text
Language:English
Published: The Korean Society of Veterinary Science 2012
Subjects:
Case Report
Canis lupus
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386349
http://www.ncbi.nlm.nih.gov/pubmed/22705746
https://doi.org/10.4142/jvs.2012.13.2.211
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Summary:Recently, we reported the three wolves cloning with normal karyotype from somatic cells of endangered male gray wolves (Canis lupus), but one wolf had female external genitalia. In this study, we conducted further clinical, histological, and genetic analyses. This cloned wolf had a normal uterus but developed ovotestis. Through molecular analysis of the SRY gene, a mutation in the coding sequence of SRY gene could be excluded as a cause of intersexuality. This is the first report of a cloned wolf with a 78, XY ovotesticular disorder affecting sexual development characterized by bilateral ovotestes.

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