SRY-positive 78, XY ovotesticular disorder of sex development in a wolf cloned by nuclear transfer
Recently, we reported the three wolves cloning with normal karyotype from somatic cells of endangered male gray wolves (Canis lupus), but one wolf had female external genitalia. In this study, we conducted further clinical, histological, and genetic analyses. This cloned wolf had a normal uterus but...
Published in: | Journal of Veterinary Science |
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Main Authors: | , , , , , , , , , |
Format: | Text |
Language: | English |
Published: |
The Korean Society of Veterinary Science
2012
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Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386349 http://www.ncbi.nlm.nih.gov/pubmed/22705746 https://doi.org/10.4142/jvs.2012.13.2.211 |
Summary: | Recently, we reported the three wolves cloning with normal karyotype from somatic cells of endangered male gray wolves (Canis lupus), but one wolf had female external genitalia. In this study, we conducted further clinical, histological, and genetic analyses. This cloned wolf had a normal uterus but developed ovotestis. Through molecular analysis of the SRY gene, a mutation in the coding sequence of SRY gene could be excluded as a cause of intersexuality. This is the first report of a cloned wolf with a 78, XY ovotesticular disorder affecting sexual development characterized by bilateral ovotestes. |
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