Relation between Methylmercury Exposure and Plasma Paraoxonase Activity in Inuit Adults from Nunavik

Background: Methylmercury (MeHg) exposure has been linked to an increased risk of coronary heart disease (CHD). Paraoxonase 1 (PON1), an enzyme located in the high-density–lipoprotein (HDL) fraction of blood lipids, may protect against CHD by metabolizing toxic oxidized lipids associated with low-de...

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Published in:Environmental Health Perspectives
Main Authors: Ayotte, Pierre, Carrier, Antoine, Ouellet, Nathalie, Boiteau, Véronique, Abdous, Belkacem, Sidi, Elhadji Anassour Laouan, Château-Degat, Marie-Ludivine, Dewailly, Éric
Format: Text
Language:English
Published: National Institute of Environmental Health Sciences 2011
Subjects:
Research
Nunavik
inuit
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237359
http://www.ncbi.nlm.nih.gov/pubmed/21543280
https://doi.org/10.1289/ehp.1003296
id ftpubmed:oai:pubmedcentral.nih.gov:3237359
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spelling ftpubmed:oai:pubmedcentral.nih.gov:3237359 2023-05-15T16:54:59+02:00 Relation between Methylmercury Exposure and Plasma Paraoxonase Activity in Inuit Adults from Nunavik Ayotte, Pierre Carrier, Antoine Ouellet, Nathalie Boiteau, Véronique Abdous, Belkacem Sidi, Elhadji Anassour Laouan Château-Degat, Marie-Ludivine Dewailly, Éric 2011-05-04 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237359 http://www.ncbi.nlm.nih.gov/pubmed/21543280 https://doi.org/10.1289/ehp.1003296 en eng National Institute of Environmental Health Sciences http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237359 http://www.ncbi.nlm.nih.gov/pubmed/21543280 http://dx.doi.org/10.1289/ehp.1003296 http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY Research Text 2011 ftpubmed https://doi.org/10.1289/ehp.1003296 2013-09-03T23:55:29Z Background: Methylmercury (MeHg) exposure has been linked to an increased risk of coronary heart disease (CHD). Paraoxonase 1 (PON1), an enzyme located in the high-density–lipoprotein (HDL) fraction of blood lipids, may protect against CHD by metabolizing toxic oxidized lipids associated with low-density liproprotein and HDL. MeHg has been shown to inhibit PON1 activity in vitro, but this effect has not been studied in human populations. Text inuit Nunavik PubMed Central (PMC) Nunavik Environmental Health Perspectives 119 8 1077 1083
institution Open Polar
collection PubMed Central (PMC)
op_collection_id ftpubmed
language English
topic Research
spellingShingle Research
Ayotte, Pierre
Carrier, Antoine
Ouellet, Nathalie
Boiteau, Véronique
Abdous, Belkacem
Sidi, Elhadji Anassour Laouan
Château-Degat, Marie-Ludivine
Dewailly, Éric
Relation between Methylmercury Exposure and Plasma Paraoxonase Activity in Inuit Adults from Nunavik
topic_facet Research
description Background: Methylmercury (MeHg) exposure has been linked to an increased risk of coronary heart disease (CHD). Paraoxonase 1 (PON1), an enzyme located in the high-density–lipoprotein (HDL) fraction of blood lipids, may protect against CHD by metabolizing toxic oxidized lipids associated with low-density liproprotein and HDL. MeHg has been shown to inhibit PON1 activity in vitro, but this effect has not been studied in human populations.
format Text
author Ayotte, Pierre
Carrier, Antoine
Ouellet, Nathalie
Boiteau, Véronique
Abdous, Belkacem
Sidi, Elhadji Anassour Laouan
Château-Degat, Marie-Ludivine
Dewailly, Éric
author_facet Ayotte, Pierre
Carrier, Antoine
Ouellet, Nathalie
Boiteau, Véronique
Abdous, Belkacem
Sidi, Elhadji Anassour Laouan
Château-Degat, Marie-Ludivine
Dewailly, Éric
author_sort Ayotte, Pierre
title Relation between Methylmercury Exposure and Plasma Paraoxonase Activity in Inuit Adults from Nunavik
title_short Relation between Methylmercury Exposure and Plasma Paraoxonase Activity in Inuit Adults from Nunavik
title_full Relation between Methylmercury Exposure and Plasma Paraoxonase Activity in Inuit Adults from Nunavik
title_fullStr Relation between Methylmercury Exposure and Plasma Paraoxonase Activity in Inuit Adults from Nunavik
title_full_unstemmed Relation between Methylmercury Exposure and Plasma Paraoxonase Activity in Inuit Adults from Nunavik
title_sort relation between methylmercury exposure and plasma paraoxonase activity in inuit adults from nunavik
publisher National Institute of Environmental Health Sciences
publishDate 2011
url http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237359
http://www.ncbi.nlm.nih.gov/pubmed/21543280
https://doi.org/10.1289/ehp.1003296
geographic Nunavik
geographic_facet Nunavik
genre inuit
Nunavik
genre_facet inuit
Nunavik
op_relation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237359
http://www.ncbi.nlm.nih.gov/pubmed/21543280
http://dx.doi.org/10.1289/ehp.1003296
op_rights http://creativecommons.org/licenses/by/2.5/
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
op_rightsnorm CC-BY
op_doi https://doi.org/10.1289/ehp.1003296
container_title Environmental Health Perspectives
container_volume 119
container_issue 8
container_start_page 1077
op_container_end_page 1083
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