Relation between Methylmercury Exposure and Plasma Paraoxonase Activity in Inuit Adults from Nunavik

Background: Methylmercury (MeHg) exposure has been linked to an increased risk of coronary heart disease (CHD). Paraoxonase 1 (PON1), an enzyme located in the high-density–lipoprotein (HDL) fraction of blood lipids, may protect against CHD by metabolizing toxic oxidized lipids associated with low-de...

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Bibliographic Details
Published in:Environmental Health Perspectives
Main Authors: Ayotte, Pierre, Carrier, Antoine, Ouellet, Nathalie, Boiteau, Véronique, Abdous, Belkacem, Sidi, Elhadji Anassour Laouan, Château-Degat, Marie-Ludivine, Dewailly, Éric
Format: Text
Language:English
Published: National Institute of Environmental Health Sciences 2011
Subjects:
Research
Nunavik
inuit
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237359
http://www.ncbi.nlm.nih.gov/pubmed/21543280
https://doi.org/10.1289/ehp.1003296
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Summary:Background: Methylmercury (MeHg) exposure has been linked to an increased risk of coronary heart disease (CHD). Paraoxonase 1 (PON1), an enzyme located in the high-density–lipoprotein (HDL) fraction of blood lipids, may protect against CHD by metabolizing toxic oxidized lipids associated with low-density liproprotein and HDL. MeHg has been shown to inhibit PON1 activity in vitro, but this effect has not been studied in human populations.

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