Relation between Methylmercury Exposure and Plasma Paraoxonase Activity in Inuit Adults from Nunavik
Background: Methylmercury (MeHg) exposure has been linked to an increased risk of coronary heart disease (CHD). Paraoxonase 1 (PON1), an enzyme located in the high-density–lipoprotein (HDL) fraction of blood lipids, may protect against CHD by metabolizing toxic oxidized lipids associated with low-de...
Published in: | Environmental Health Perspectives |
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Main Authors: | , , , , , , , |
Format: | Text |
Language: | English |
Published: |
National Institute of Environmental Health Sciences
2011
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Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237359 http://www.ncbi.nlm.nih.gov/pubmed/21543280 https://doi.org/10.1289/ehp.1003296 |
Summary: | Background: Methylmercury (MeHg) exposure has been linked to an increased risk of coronary heart disease (CHD). Paraoxonase 1 (PON1), an enzyme located in the high-density–lipoprotein (HDL) fraction of blood lipids, may protect against CHD by metabolizing toxic oxidized lipids associated with low-density liproprotein and HDL. MeHg has been shown to inhibit PON1 activity in vitro, but this effect has not been studied in human populations. |
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