Synthesis of NanoQ, a Copper-Based Contrast Agent, for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus
Based on a nanocolloidal suspension of lipid-encapsulated, organically-soluble bivalent copper, a new site-targeted molecular imaging contrast agent has been developed. Concentrating high payload of bivalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity allowing...
Published in: | Journal of the American Chemical Society |
---|---|
Main Authors: | , , , , , , , , , |
Format: | Text |
Language: | English |
Published: |
2011
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124378 http://www.ncbi.nlm.nih.gov/pubmed/21599030 https://doi.org/10.1021/ja201918u |
id |
ftpubmed:oai:pubmedcentral.nih.gov:3124378 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:3124378 2023-05-15T17:14:02+02:00 Synthesis of NanoQ, a Copper-Based Contrast Agent, for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus Pan, Dipanjan Caruthers, Shelton D. Senpan, Angana Yalaz, Ceren Stacy, Allen J. Hu, Grace Marsh, Jon N. Gaffney, Patrick J. Wickline, Samuel A. Lanza, Gregory M. 2011-05-26 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124378 http://www.ncbi.nlm.nih.gov/pubmed/21599030 https://doi.org/10.1021/ja201918u en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124378 http://www.ncbi.nlm.nih.gov/pubmed/21599030 http://dx.doi.org/10.1021/ja201918u Article Text 2011 ftpubmed https://doi.org/10.1021/ja201918u 2013-09-03T16:35:07Z Based on a nanocolloidal suspension of lipid-encapsulated, organically-soluble bivalent copper, a new site-targeted molecular imaging contrast agent has been developed. Concentrating high payload of bivalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity allowing sensitive detection on T1-weighted MRI as is demonstrated herein targeted to fibrin clots in vitro. The particle also exhibits a defined clearance and safety profile in vivo. Text nanoq PubMed Central (PMC) Journal of the American Chemical Society 133 24 9168 9171 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Article |
spellingShingle |
Article Pan, Dipanjan Caruthers, Shelton D. Senpan, Angana Yalaz, Ceren Stacy, Allen J. Hu, Grace Marsh, Jon N. Gaffney, Patrick J. Wickline, Samuel A. Lanza, Gregory M. Synthesis of NanoQ, a Copper-Based Contrast Agent, for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus |
topic_facet |
Article |
description |
Based on a nanocolloidal suspension of lipid-encapsulated, organically-soluble bivalent copper, a new site-targeted molecular imaging contrast agent has been developed. Concentrating high payload of bivalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity allowing sensitive detection on T1-weighted MRI as is demonstrated herein targeted to fibrin clots in vitro. The particle also exhibits a defined clearance and safety profile in vivo. |
format |
Text |
author |
Pan, Dipanjan Caruthers, Shelton D. Senpan, Angana Yalaz, Ceren Stacy, Allen J. Hu, Grace Marsh, Jon N. Gaffney, Patrick J. Wickline, Samuel A. Lanza, Gregory M. |
author_facet |
Pan, Dipanjan Caruthers, Shelton D. Senpan, Angana Yalaz, Ceren Stacy, Allen J. Hu, Grace Marsh, Jon N. Gaffney, Patrick J. Wickline, Samuel A. Lanza, Gregory M. |
author_sort |
Pan, Dipanjan |
title |
Synthesis of NanoQ, a Copper-Based Contrast Agent, for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus |
title_short |
Synthesis of NanoQ, a Copper-Based Contrast Agent, for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus |
title_full |
Synthesis of NanoQ, a Copper-Based Contrast Agent, for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus |
title_fullStr |
Synthesis of NanoQ, a Copper-Based Contrast Agent, for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus |
title_full_unstemmed |
Synthesis of NanoQ, a Copper-Based Contrast Agent, for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus |
title_sort |
synthesis of nanoq, a copper-based contrast agent, for high-resolution magnetic resonance imaging characterization of human thrombus |
publishDate |
2011 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124378 http://www.ncbi.nlm.nih.gov/pubmed/21599030 https://doi.org/10.1021/ja201918u |
genre |
nanoq |
genre_facet |
nanoq |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124378 http://www.ncbi.nlm.nih.gov/pubmed/21599030 http://dx.doi.org/10.1021/ja201918u |
op_doi |
https://doi.org/10.1021/ja201918u |
container_title |
Journal of the American Chemical Society |
container_volume |
133 |
container_issue |
24 |
container_start_page |
9168 |
op_container_end_page |
9171 |
_version_ |
1766071285709799424 |