Synthesis of NanoQ, a Copper-Based Contrast Agent, for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus

Based on a nanocolloidal suspension of lipid-encapsulated, organically-soluble bivalent copper, a new site-targeted molecular imaging contrast agent has been developed. Concentrating high payload of bivalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity allowing...

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Published in:Journal of the American Chemical Society
Main Authors: Pan, Dipanjan, Caruthers, Shelton D., Senpan, Angana, Yalaz, Ceren, Stacy, Allen J., Hu, Grace, Marsh, Jon N., Gaffney, Patrick J., Wickline, Samuel A., Lanza, Gregory M.
Format: Text
Language:English
Published: 2011
Subjects:
Article
nanoq
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124378
http://www.ncbi.nlm.nih.gov/pubmed/21599030
https://doi.org/10.1021/ja201918u
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spelling ftpubmed:oai:pubmedcentral.nih.gov:3124378 2023-05-15T17:14:02+02:00 Synthesis of NanoQ, a Copper-Based Contrast Agent, for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus Pan, Dipanjan Caruthers, Shelton D. Senpan, Angana Yalaz, Ceren Stacy, Allen J. Hu, Grace Marsh, Jon N. Gaffney, Patrick J. Wickline, Samuel A. Lanza, Gregory M. 2011-05-26 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124378 http://www.ncbi.nlm.nih.gov/pubmed/21599030 https://doi.org/10.1021/ja201918u en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124378 http://www.ncbi.nlm.nih.gov/pubmed/21599030 http://dx.doi.org/10.1021/ja201918u Article Text 2011 ftpubmed https://doi.org/10.1021/ja201918u 2013-09-03T16:35:07Z Based on a nanocolloidal suspension of lipid-encapsulated, organically-soluble bivalent copper, a new site-targeted molecular imaging contrast agent has been developed. Concentrating high payload of bivalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity allowing sensitive detection on T1-weighted MRI as is demonstrated herein targeted to fibrin clots in vitro. The particle also exhibits a defined clearance and safety profile in vivo. Text nanoq PubMed Central (PMC) Journal of the American Chemical Society 133 24 9168 9171
institution Open Polar
collection PubMed Central (PMC)
op_collection_id ftpubmed
language English
topic Article
spellingShingle Article
Pan, Dipanjan
Caruthers, Shelton D.
Senpan, Angana
Yalaz, Ceren
Stacy, Allen J.
Hu, Grace
Marsh, Jon N.
Gaffney, Patrick J.
Wickline, Samuel A.
Lanza, Gregory M.
Synthesis of NanoQ, a Copper-Based Contrast Agent, for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus
topic_facet Article
description Based on a nanocolloidal suspension of lipid-encapsulated, organically-soluble bivalent copper, a new site-targeted molecular imaging contrast agent has been developed. Concentrating high payload of bivalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity allowing sensitive detection on T1-weighted MRI as is demonstrated herein targeted to fibrin clots in vitro. The particle also exhibits a defined clearance and safety profile in vivo.
format Text
author Pan, Dipanjan
Caruthers, Shelton D.
Senpan, Angana
Yalaz, Ceren
Stacy, Allen J.
Hu, Grace
Marsh, Jon N.
Gaffney, Patrick J.
Wickline, Samuel A.
Lanza, Gregory M.
author_facet Pan, Dipanjan
Caruthers, Shelton D.
Senpan, Angana
Yalaz, Ceren
Stacy, Allen J.
Hu, Grace
Marsh, Jon N.
Gaffney, Patrick J.
Wickline, Samuel A.
Lanza, Gregory M.
author_sort Pan, Dipanjan
title Synthesis of NanoQ, a Copper-Based Contrast Agent, for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus
title_short Synthesis of NanoQ, a Copper-Based Contrast Agent, for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus
title_full Synthesis of NanoQ, a Copper-Based Contrast Agent, for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus
title_fullStr Synthesis of NanoQ, a Copper-Based Contrast Agent, for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus
title_full_unstemmed Synthesis of NanoQ, a Copper-Based Contrast Agent, for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus
title_sort synthesis of nanoq, a copper-based contrast agent, for high-resolution magnetic resonance imaging characterization of human thrombus
publishDate 2011
url http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124378
http://www.ncbi.nlm.nih.gov/pubmed/21599030
https://doi.org/10.1021/ja201918u
genre nanoq
genre_facet nanoq
op_relation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124378
http://www.ncbi.nlm.nih.gov/pubmed/21599030
http://dx.doi.org/10.1021/ja201918u
op_doi https://doi.org/10.1021/ja201918u
container_title Journal of the American Chemical Society
container_volume 133
container_issue 24
container_start_page 9168
op_container_end_page 9171
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