Synthesis of NanoQ, a Copper-Based Contrast Agent, for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus
Based on a nanocolloidal suspension of lipid-encapsulated, organically-soluble bivalent copper, a new site-targeted molecular imaging contrast agent has been developed. Concentrating high payload of bivalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity allowing...
Published in: | Journal of the American Chemical Society |
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Main Authors: | , , , , , , , , , |
Format: | Text |
Language: | English |
Published: |
2011
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Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124378 http://www.ncbi.nlm.nih.gov/pubmed/21599030 https://doi.org/10.1021/ja201918u |
Summary: | Based on a nanocolloidal suspension of lipid-encapsulated, organically-soluble bivalent copper, a new site-targeted molecular imaging contrast agent has been developed. Concentrating high payload of bivalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity allowing sensitive detection on T1-weighted MRI as is demonstrated herein targeted to fibrin clots in vitro. The particle also exhibits a defined clearance and safety profile in vivo. |
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