Synthesis of NanoQ, a Copper-Based Contrast Agent, for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus

Based on a nanocolloidal suspension of lipid-encapsulated, organically-soluble bivalent copper, a new site-targeted molecular imaging contrast agent has been developed. Concentrating high payload of bivalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity allowing...

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Bibliographic Details
Published in:Journal of the American Chemical Society
Main Authors: Pan, Dipanjan, Caruthers, Shelton D., Senpan, Angana, Yalaz, Ceren, Stacy, Allen J., Hu, Grace, Marsh, Jon N., Gaffney, Patrick J., Wickline, Samuel A., Lanza, Gregory M.
Format: Text
Language:English
Published: 2011
Subjects:
Article
nanoq
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124378
http://www.ncbi.nlm.nih.gov/pubmed/21599030
https://doi.org/10.1021/ja201918u
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Summary:Based on a nanocolloidal suspension of lipid-encapsulated, organically-soluble bivalent copper, a new site-targeted molecular imaging contrast agent has been developed. Concentrating high payload of bivalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity allowing sensitive detection on T1-weighted MRI as is demonstrated herein targeted to fibrin clots in vitro. The particle also exhibits a defined clearance and safety profile in vivo.

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