Phylogenetic discordance of human and canine carcinoembryonic antigen (CEA, CEACAM) families, but striking identity of the CEA receptors will impact comparative oncology studies.

Comparative oncology aims at speeding up developments for both, human and companion animal cancer patients. Following this line, carcinoembryonic antigen (CEA, CEACAM5) could be a therapeutic target not only for human but also for canine (Canis lupus familiaris; dog) patients. CEACAM5 interacts with...

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Bibliographic Details
Published in:PLoS Currents
Main Authors: Weichselbaumer, Marlene, Willmann, Michael, Reifinger, Martin, Singer, Josef, Bajna, Erika, Sobanov, Yuriy, Mechtcherikova, Diana, Selzer, Edgar, Thalhammer, Johann G., Kammerer, Robert, Jensen-Jarolim, Erika
Format: Text
Language:English
Published: Public Library of Science 2011
Subjects:
Tree of Life
Canis lupus
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059814
http://www.ncbi.nlm.nih.gov/pubmed/21436956
https://doi.org/10.1371/currents.RRN1223
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Summary:Comparative oncology aims at speeding up developments for both, human and companion animal cancer patients. Following this line, carcinoembryonic antigen (CEA, CEACAM5) could be a therapeutic target not only for human but also for canine (Canis lupus familiaris; dog) patients. CEACAM5 interacts with CEA-receptor (CEAR) in the cytoplasm of human cancer cells. Our aim was, therefore, to phylogenetically verify the antigenic relationship of CEACAM molecules and CEAR in human and canine cancer.

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