Mannose-Binding Lectin Genotypes and Susceptibility to Epstein-Barr Virus Infection in Infancy▿

In a cohort study of children <4 years of age in Greenland, mannose-binding lectin (MBL2) genotypes and Epstein-Barr virus (EBV) antibody levels were determined. EBV seropositivity was significantly lower and time to seroconversion increased in MBL-insufficient compared with MBL-sufficient childr...

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Bibliographic Details
Published in:Clinical and Vaccine Immunology
Main Authors: Friborg, Jeppe T., Jarrett, Ruth F., Koch, Anders, Garred, Peter, Freeland, June M. L., Andersen, Andreas, Melbye, Mads
Format: Text
Language:English
Published: American Society for Microbiology (ASM) 2010
Subjects:
Microbial Immunology
Greenland
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944456
http://www.ncbi.nlm.nih.gov/pubmed/20610664
https://doi.org/10.1128/CVI.00527-09
Description
Summary:In a cohort study of children <4 years of age in Greenland, mannose-binding lectin (MBL2) genotypes and Epstein-Barr virus (EBV) antibody levels were determined. EBV seropositivity was significantly lower and time to seroconversion increased in MBL-insufficient compared with MBL-sufficient children, indicating that MBL may be involved in primary EBV infection in infancy.

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