Synthesis of 3-Alkyl Pyridinium Alkaloids from the Arctic Sponge Haliclona viscosa

3-Alkyl pyridinium alkaloids (3-APAs) are common secondary metabolites in marine sponges of the order Haplosclerida. In recent years, our laboratory has isolated and synthesized several new members of this family such as haliclamines C–F, viscosamine, viscosaline and a cyclic monomer. All of them we...

Full description

Bibliographic Details
Published in:Marine Drugs
Main Authors: Timm, Christoph, Mordhorst, Thorsten, Köck, Matthias
Format: Text
Language:English
Published: Molecular Diversity Preservation International 2010
Subjects:
Review
Arctic
Norway
Spitsbergen
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857371
http://www.ncbi.nlm.nih.gov/pubmed/20411111
https://doi.org/10.3390/md8030483
Description
Summary:3-Alkyl pyridinium alkaloids (3-APAs) are common secondary metabolites in marine sponges of the order Haplosclerida. In recent years, our laboratory has isolated and synthesized several new members of this family such as haliclamines C–F, viscosamine, viscosaline and a cyclic monomer. All of them were isolated from the Arctic sponge Haliclona viscosa collected in Spitsbergen, Norway. In this article we report the syntheses of these secondary metabolites from Haliclona viscosa and related compounds and give a short overview of the bioactivity.

Similar Items