Relation between stable isotope ratios in human red blood cells and hair: implications for using the nitrogen isotope ratio of hair as a biomarker of eicosapentaenoic acid and docosahexaenoic acid1234

Background: The nitrogen isotope ratio (expressed as δ15N) of red blood cells (RBCs) is highly correlated with the RBC long-chain ω−3 (n−3) fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in Yup'ik Eskimos. Because δ15N can also be measured in hair samples, it could provi...

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Bibliographic Details
Published in:The American Journal of Clinical Nutrition
Main Authors: Nash, Sarah H, Kristal, Alan R, Boyer, Bert B, King, Irena B, Metzgar, Jordan S, O'Brien, Diane M
Format: Text
Language:English
Published: American Society for Nutrition 2009
Subjects:
Nutritional epidemiology and public health
eskimo*
Yup'ik
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777473
http://www.ncbi.nlm.nih.gov/pubmed/19864410
https://doi.org/10.3945/ajcn.2009.28482
Description
Summary:Background: The nitrogen isotope ratio (expressed as δ15N) of red blood cells (RBCs) is highly correlated with the RBC long-chain ω−3 (n−3) fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in Yup'ik Eskimos. Because δ15N can also be measured in hair samples, it could provide a noninvasive, retrospective biomarker for EPA and DHA intakes.

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