The development and evaluation of a continuous flow process for the lipase-mediated oxidation of alkenes

We report the use of an immobilised form of Candida antarctica lipase B, Novozym® 435, in a preliminary investigation into the development of a continuous flow reactor capable of performing the chemo-enzymatic oxidation of alkenes in high yield and purity, utilising the commercially available oxidan...

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Published in:Beilstein Journal of Organic Chemistry
Main Authors: Wiles, Charlotte, Hammond, Marcus J, Watts, Paul
Format: Text
Language:English
Published: Beilstein-Institut 2009
Subjects:
Full Research Paper
Antarc*
Antarctica
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707024
http://www.ncbi.nlm.nih.gov/pubmed/19590744
https://doi.org/10.3762/bjoc.5.27
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spelling ftpubmed:oai:pubmedcentral.nih.gov:2707024 2023-05-15T13:45:44+02:00 The development and evaluation of a continuous flow process for the lipase-mediated oxidation of alkenes Wiles, Charlotte Hammond, Marcus J Watts, Paul 2009-06-02 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707024 http://www.ncbi.nlm.nih.gov/pubmed/19590744 https://doi.org/10.3762/bjoc.5.27 en eng Beilstein-Institut http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707024 http://www.ncbi.nlm.nih.gov/pubmed/19590744 http://dx.doi.org/10.3762/bjoc.5.27 Copyright © 2009, Wiles et al; licensee Beilstein-Institut. http://www.beilstein-journals.org/bjoc This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc) CC-BY Full Research Paper Text 2009 ftpubmed https://doi.org/10.3762/bjoc.5.27 2013-09-02T14:32:11Z We report the use of an immobilised form of Candida antarctica lipase B, Novozym® 435, in a preliminary investigation into the development of a continuous flow reactor capable of performing the chemo-enzymatic oxidation of alkenes in high yield and purity, utilising the commercially available oxidant hydrogen peroxide (100 volumes). Initial investigations focussed on the lipase-mediated oxidation of 1-methylcyclohexene, with the optimised reaction conditions subsequently employed for the epoxidation of an array of aromatic and aliphatic alkenes in 97.6 to 99.5% yield and quantitative purity. Text Antarc* Antarctica PubMed Central (PMC) Beilstein Journal of Organic Chemistry 5
institution Open Polar
collection PubMed Central (PMC)
op_collection_id ftpubmed
language English
topic Full Research Paper
spellingShingle Full Research Paper
Wiles, Charlotte
Hammond, Marcus J
Watts, Paul
The development and evaluation of a continuous flow process for the lipase-mediated oxidation of alkenes
topic_facet Full Research Paper
description We report the use of an immobilised form of Candida antarctica lipase B, Novozym® 435, in a preliminary investigation into the development of a continuous flow reactor capable of performing the chemo-enzymatic oxidation of alkenes in high yield and purity, utilising the commercially available oxidant hydrogen peroxide (100 volumes). Initial investigations focussed on the lipase-mediated oxidation of 1-methylcyclohexene, with the optimised reaction conditions subsequently employed for the epoxidation of an array of aromatic and aliphatic alkenes in 97.6 to 99.5% yield and quantitative purity.
format Text
author Wiles, Charlotte
Hammond, Marcus J
Watts, Paul
author_facet Wiles, Charlotte
Hammond, Marcus J
Watts, Paul
author_sort Wiles, Charlotte
title The development and evaluation of a continuous flow process for the lipase-mediated oxidation of alkenes
title_short The development and evaluation of a continuous flow process for the lipase-mediated oxidation of alkenes
title_full The development and evaluation of a continuous flow process for the lipase-mediated oxidation of alkenes
title_fullStr The development and evaluation of a continuous flow process for the lipase-mediated oxidation of alkenes
title_full_unstemmed The development and evaluation of a continuous flow process for the lipase-mediated oxidation of alkenes
title_sort development and evaluation of a continuous flow process for the lipase-mediated oxidation of alkenes
publisher Beilstein-Institut
publishDate 2009
url http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707024
http://www.ncbi.nlm.nih.gov/pubmed/19590744
https://doi.org/10.3762/bjoc.5.27
genre Antarc*
Antarctica
genre_facet Antarc*
Antarctica
op_relation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707024
http://www.ncbi.nlm.nih.gov/pubmed/19590744
http://dx.doi.org/10.3762/bjoc.5.27
op_rights Copyright © 2009, Wiles et al; licensee Beilstein-Institut.
http://www.beilstein-journals.org/bjoc
This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)
op_rightsnorm CC-BY
op_doi https://doi.org/10.3762/bjoc.5.27
container_title Beilstein Journal of Organic Chemistry
container_volume 5
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