The development and evaluation of a continuous flow process for the lipase-mediated oxidation of alkenes
We report the use of an immobilised form of Candida antarctica lipase B, Novozym® 435, in a preliminary investigation into the development of a continuous flow reactor capable of performing the chemo-enzymatic oxidation of alkenes in high yield and purity, utilising the commercially available oxidan...
| Published in: | Beilstein Journal of Organic Chemistry |
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| Main Authors: | , , |
| Format: | Text |
| Language: | English |
| Published: |
Beilstein-Institut
2009
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| Subjects: | |
| Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707024 http://www.ncbi.nlm.nih.gov/pubmed/19590744 https://doi.org/10.3762/bjoc.5.27 |
| Summary: | We report the use of an immobilised form of Candida antarctica lipase B, Novozym® 435, in a preliminary investigation into the development of a continuous flow reactor capable of performing the chemo-enzymatic oxidation of alkenes in high yield and purity, utilising the commercially available oxidant hydrogen peroxide (100 volumes). Initial investigations focussed on the lipase-mediated oxidation of 1-methylcyclohexene, with the optimised reaction conditions subsequently employed for the epoxidation of an array of aromatic and aliphatic alkenes in 97.6 to 99.5% yield and quantitative purity. |
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