N-acylation of ethanolamine using lipase: a chemoselective catalyst

The N-acylation of ethanolamine (2) with various fatty acids 1a–d and esters of fatty acids 1e–h using Candida antarctica B lipase (Novozym® 435) are described and optimum conditions for selective N-acylation rather than O-acylation are also discussed. Microwave assisted solution phase, solid suppor...

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Published in:Beilstein Journal of Organic Chemistry
Main Authors: Kidwai, Mazaahir, Poddar, Roona, Mothsra, Poonam
Format: Text
Language:English
Published: Beilstein-Institut 2009
Subjects:
Preliminary Communication
Antarc*
Antarctica
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686314
http://www.ncbi.nlm.nih.gov/pubmed/19478911
https://doi.org/10.3762/bjoc.5.10
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spelling ftpubmed:oai:pubmedcentral.nih.gov:2686314 2023-05-15T13:39:48+02:00 N-acylation of ethanolamine using lipase: a chemoselective catalyst Kidwai, Mazaahir Poddar, Roona Mothsra, Poonam 2009-03-25 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686314 http://www.ncbi.nlm.nih.gov/pubmed/19478911 https://doi.org/10.3762/bjoc.5.10 en eng Beilstein-Institut http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686314 http://www.ncbi.nlm.nih.gov/pubmed/19478911 http://dx.doi.org/10.3762/bjoc.5.10 Copyright © 2009, Kidwai et al; licensee Beilstein-Institut. http://www.beilstein-journals.org/bjoc This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc) CC-BY Preliminary Communication Text 2009 ftpubmed https://doi.org/10.3762/bjoc.5.10 2013-09-02T13:18:30Z The N-acylation of ethanolamine (2) with various fatty acids 1a–d and esters of fatty acids 1e–h using Candida antarctica B lipase (Novozym® 435) are described and optimum conditions for selective N-acylation rather than O-acylation are also discussed. Microwave assisted solution phase, solid supported and conventional methods were investigated and results were compared. There is a synergy between the enzyme catalysis and microwave irradiation. Text Antarc* Antarctica PubMed Central (PMC) Beilstein Journal of Organic Chemistry 5
institution Open Polar
collection PubMed Central (PMC)
op_collection_id ftpubmed
language English
topic Preliminary Communication
spellingShingle Preliminary Communication
Kidwai, Mazaahir
Poddar, Roona
Mothsra, Poonam
N-acylation of ethanolamine using lipase: a chemoselective catalyst
topic_facet Preliminary Communication
description The N-acylation of ethanolamine (2) with various fatty acids 1a–d and esters of fatty acids 1e–h using Candida antarctica B lipase (Novozym® 435) are described and optimum conditions for selective N-acylation rather than O-acylation are also discussed. Microwave assisted solution phase, solid supported and conventional methods were investigated and results were compared. There is a synergy between the enzyme catalysis and microwave irradiation.
format Text
author Kidwai, Mazaahir
Poddar, Roona
Mothsra, Poonam
author_facet Kidwai, Mazaahir
Poddar, Roona
Mothsra, Poonam
author_sort Kidwai, Mazaahir
title N-acylation of ethanolamine using lipase: a chemoselective catalyst
title_short N-acylation of ethanolamine using lipase: a chemoselective catalyst
title_full N-acylation of ethanolamine using lipase: a chemoselective catalyst
title_fullStr N-acylation of ethanolamine using lipase: a chemoselective catalyst
title_full_unstemmed N-acylation of ethanolamine using lipase: a chemoselective catalyst
title_sort n-acylation of ethanolamine using lipase: a chemoselective catalyst
publisher Beilstein-Institut
publishDate 2009
url http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686314
http://www.ncbi.nlm.nih.gov/pubmed/19478911
https://doi.org/10.3762/bjoc.5.10
genre Antarc*
Antarctica
genre_facet Antarc*
Antarctica
op_relation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686314
http://www.ncbi.nlm.nih.gov/pubmed/19478911
http://dx.doi.org/10.3762/bjoc.5.10
op_rights Copyright © 2009, Kidwai et al; licensee Beilstein-Institut.
http://www.beilstein-journals.org/bjoc
This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)
op_rightsnorm CC-BY
op_doi https://doi.org/10.3762/bjoc.5.10
container_title Beilstein Journal of Organic Chemistry
container_volume 5
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